Covid-19 in a patient receiving adjuvant breast cancer chemotherapy with granulocyte olony-stimulating factor (G-csf) support: A case report

Rinat Yerushalmi, Moshe Sagi, Hadar Goldvaser, Jonathan Daliot, Raz Mutai, Ilan Krause

Research output: Contribution to journalArticlepeer-review

Abstract

Patients receiving chemotherapy are at high risk for severe infections and complications such as acute respiratory syndrome. The most commonly used adjuvant chemotherapy protocols (docetaxel-cyclophosphamide every 3 weeks or the dose-dense regimen, doxorubicin-cyclophosphamide every 2 weeks followed by paclitaxel) incorporate granulocyte-colony stimulating factor (G-CSF). G-CSF is routinely administered to prevent chemotherapy-associated neutropenia but often results in significant neutrophilia. The present case describes a patient with breast cancer who was successfully treated for severe COVID-19 respiratory syndrome while under adjuvant chemotherapy (docetaxel-cyclophosphamide) treatment and long-term G-CSF support. In addition, the potential effect of G-CSF on the respiratory deterioration of the patient given its cardinal role in innate inflammation and, accordingly, the cytokine storm associated with COVID-19 was described. The case described in the present study indicated how solutions to the immunity challenges faced when treating a patient with chemotherapy may be the source of a larger problem within the coronavirus COVID-19 pandemic.

Original languageEnglish
Article number117
JournalMolecular and Clinical Oncology
Volume14
Issue number6
DOIs
StatePublished - 2021

Keywords

  • Breast cancer
  • COVID-19
  • Chemotherapy
  • Granulocyte-colony stimulating factor
  • Respiratory syndrome

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