TY - JOUR
T1 - Coulometric Titration of Hydroxyurea
AU - Dosortzev, Vladimir
AU - Kirowa-Eisner, Emilia
PY - 1997/9
Y1 - 1997/9
N2 - Hydroxyurea, HXU, is quantitatively determined by electrochemically generated bromine. The overall reaction between HXU and Br2 is studied and determined to be NH2CONHOH + Br2 + 1/2H2O + HBr + NH4Br + CO2 + 1/2N2O. The titrations are performed in the monotonie consecutive mode with the use of a nonisolated counter electrode. The end point is detected amperometrically (with a gold or platinum indicating electrode) or potentiometrically (with a gold indicating electrode). The chemical composition of the solution is 0.4 M KBr in acetate buffer. Concentrations of HXU in the range from 5 mM to 0.1 mM are determined with a standard deviation of 1-2%, respectively.
AB - Hydroxyurea, HXU, is quantitatively determined by electrochemically generated bromine. The overall reaction between HXU and Br2 is studied and determined to be NH2CONHOH + Br2 + 1/2H2O + HBr + NH4Br + CO2 + 1/2N2O. The titrations are performed in the monotonie consecutive mode with the use of a nonisolated counter electrode. The end point is detected amperometrically (with a gold or platinum indicating electrode) or potentiometrically (with a gold indicating electrode). The chemical composition of the solution is 0.4 M KBr in acetate buffer. Concentrations of HXU in the range from 5 mM to 0.1 mM are determined with a standard deviation of 1-2%, respectively.
UR - http://www.scopus.com/inward/record.url?scp=0346541669&partnerID=8YFLogxK
U2 - 10.1006/mchj.1997.1507
DO - 10.1006/mchj.1997.1507
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AN - SCOPUS:0346541669
SN - 0026-265X
VL - 57
SP - 96
EP - 109
JO - Microchemical Journal
JF - Microchemical Journal
IS - 1
ER -