Coulometric Titration of Hydroxyurea

Vladimir Dosortzev*, Emilia Kirowa-Eisner

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Hydroxyurea, HXU, is quantitatively determined by electrochemically generated bromine. The overall reaction between HXU and Br2 is studied and determined to be NH2CONHOH + Br2 + 1/2H2O + HBr + NH4Br + CO2 + 1/2N2O. The titrations are performed in the monotonie consecutive mode with the use of a nonisolated counter electrode. The end point is detected amperometrically (with a gold or platinum indicating electrode) or potentiometrically (with a gold indicating electrode). The chemical composition of the solution is 0.4 M KBr in acetate buffer. Concentrations of HXU in the range from 5 mM to 0.1 mM are determined with a standard deviation of 1-2%, respectively.

Original languageEnglish
Pages (from-to)96-109
Number of pages14
JournalMicrochemical Journal
Issue number1
StatePublished - Sep 1997


Dive into the research topics of 'Coulometric Titration of Hydroxyurea'. Together they form a unique fingerprint.

Cite this