TY - JOUR
T1 - Cortisol metabolism in lymphocytes isolated from patients with different diseases (multiple sclerosis, Cushing's disease, and inflammatory diseases)
AU - Klein, Ami
AU - Martfel, Josef
AU - Kaufmann, Haiuta
AU - Hoogervorst-Spalter, Henriette
AU - Bechar, Mordechai
N1 - Funding Information:
Acknowledgements--The expenses of the investigations of this manuscript were defrayed by the Israel Cancer Research Fund (George and Rose Blumenthal Research Fellowship for Hodgkin's Disease). The authors are grateful to Dr. Malchi and his staff at the Beilinson Medical Center Blood Bank for supplying us with buffy coat. We also thank Mrs. R. Fradkin and Mrs. C. Sachs for revising and typing the paper.
PY - 1980/4
Y1 - 1980/4
N2 - A study was undertaken to determine the cortisol conversion rate of lymphocytes from 29 patients suffering from various diseases, including neurological diseases sensitive to steroid treatment (multiple sclerosis, during both remission and relapse), diseases with hyperproduction of cortisol (Cushing's disease) and patients with some form of acute inflammatory diseases. For the purposes of control, lymphocytes obtained from 26 healthy donors were also tested. The mean conversion rate of all groups, with the exception of the patients with inflammatory disease, was similar to the mean rate in the control group. The mean rate of patients with inflammatory disease was 2.4 times higher than that of the controls. Among the patients with multiple sclerosis, no significant difference was found between those undergoing relapse and those in remission. Thus it would appear that a high rate of cortisol metabolism by lymphocytes is a characteristic not only of malignancy, but also of an inflammatory processes.
AB - A study was undertaken to determine the cortisol conversion rate of lymphocytes from 29 patients suffering from various diseases, including neurological diseases sensitive to steroid treatment (multiple sclerosis, during both remission and relapse), diseases with hyperproduction of cortisol (Cushing's disease) and patients with some form of acute inflammatory diseases. For the purposes of control, lymphocytes obtained from 26 healthy donors were also tested. The mean conversion rate of all groups, with the exception of the patients with inflammatory disease, was similar to the mean rate in the control group. The mean rate of patients with inflammatory disease was 2.4 times higher than that of the controls. Among the patients with multiple sclerosis, no significant difference was found between those undergoing relapse and those in remission. Thus it would appear that a high rate of cortisol metabolism by lymphocytes is a characteristic not only of malignancy, but also of an inflammatory processes.
UR - http://www.scopus.com/inward/record.url?scp=0019314175&partnerID=8YFLogxK
U2 - 10.1016/0022-4731(80)90345-3
DO - 10.1016/0022-4731(80)90345-3
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AN - SCOPUS:0019314175
VL - 13
SP - 401
EP - 404
JO - Journal of Steroid Biochemistry and Molecular Biology
JF - Journal of Steroid Biochemistry and Molecular Biology
SN - 0960-0760
IS - 4
ER -