Cortisol metabolism in lymphocytes isolated from patients with different diseases (multiple sclerosis, Cushing's disease, and inflammatory diseases)

Ami Klein, Josef Martfel, Haiuta Kaufmann, Henriette Hoogervorst-Spalter, Mordechai Bechar

Research output: Contribution to journalArticlepeer-review

Abstract

A study was undertaken to determine the cortisol conversion rate of lymphocytes from 29 patients suffering from various diseases, including neurological diseases sensitive to steroid treatment (multiple sclerosis, during both remission and relapse), diseases with hyperproduction of cortisol (Cushing's disease) and patients with some form of acute inflammatory diseases. For the purposes of control, lymphocytes obtained from 26 healthy donors were also tested. The mean conversion rate of all groups, with the exception of the patients with inflammatory disease, was similar to the mean rate in the control group. The mean rate of patients with inflammatory disease was 2.4 times higher than that of the controls. Among the patients with multiple sclerosis, no significant difference was found between those undergoing relapse and those in remission. Thus it would appear that a high rate of cortisol metabolism by lymphocytes is a characteristic not only of malignancy, but also of an inflammatory processes.

Original languageEnglish
Pages (from-to)401-404
Number of pages4
JournalJournal of Steroid Biochemistry
Volume13
Issue number4
DOIs
StatePublished - Apr 1980
Externally publishedYes

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