TY - JOUR
T1 - Cortisol metabolism in lymphocytes from cancer-bearing patients
AU - Klein, Ami
AU - Kaufmann, Haiuta
AU - Mannheimer, Shoshana
AU - Joshua, Henry
N1 - Funding Information:
Petah Tiqva. Israel. Received for publication August 18. 1977. Supported by the Israel Cancer Research Fund (George and Rose Blumenthal Research Fellow-shipJor Hodgkin’s Disease). Address reprint requests to Dr. Ami Klein, Endocrinological Laboratory, Beilinson Medical Center, Petah Tiqva,‘israel. 0 1978 by Grune & Stratton, Inc. 0026-0495/78/270&0011$01.00/0
PY - 1978/6
Y1 - 1978/6
N2 - A study was conducted to determine the pattern of cortisol metabolism by lymphocytes obtained from four groups of subjects: 27 male and female patients suffering from various types of malignancy other than malignancy of lymphatic tissues; and 26 healthy male and female controls. Known concentrations of cells were incubated with 1,2-3H-cortisol and the products were isolated by thin-layer and paper chromatography. Three metabolites were found to be produced by lymphocytes from both normal and cancer-bearing patients: 20α-hydroxycortisol, 20β-hydroxycortisol, and tetrahydrocortisol. Cells from the female control group were found to be more active than those from the male controls, while cells from cancer-bearing patients were markedly more active than the normal cells, regardless of sex. It is suggested that this finding of increased metabolism of cortisol by lymphocytes from patients with different types of malignancy other than lymphoma may provide the basis for a new diagnostic aid.
AB - A study was conducted to determine the pattern of cortisol metabolism by lymphocytes obtained from four groups of subjects: 27 male and female patients suffering from various types of malignancy other than malignancy of lymphatic tissues; and 26 healthy male and female controls. Known concentrations of cells were incubated with 1,2-3H-cortisol and the products were isolated by thin-layer and paper chromatography. Three metabolites were found to be produced by lymphocytes from both normal and cancer-bearing patients: 20α-hydroxycortisol, 20β-hydroxycortisol, and tetrahydrocortisol. Cells from the female control group were found to be more active than those from the male controls, while cells from cancer-bearing patients were markedly more active than the normal cells, regardless of sex. It is suggested that this finding of increased metabolism of cortisol by lymphocytes from patients with different types of malignancy other than lymphoma may provide the basis for a new diagnostic aid.
UR - http://www.scopus.com/inward/record.url?scp=0018103061&partnerID=8YFLogxK
U2 - 10.1016/0026-0495(78)90011-2
DO - 10.1016/0026-0495(78)90011-2
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AN - SCOPUS:0018103061
SN - 0026-0495
VL - 27
SP - 731
EP - 736
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
IS - 6
ER -
