Corticosteroid effect on eosinophils in vitro: ultrastructural studies

M. Djaldetti, P. Fishman, H. Bessler, E. Van Der Lijn

Research output: Contribution to journalArticlepeer-review


The effect of corticosteroids, ultracortene and ACTH, on the eosinophilic cells of a patient with hypereosinophilic syndrome has been studied in vitro. Both drugs caused a marked decrease in the number of specific granules, a disappearance of their surrounding membrane and an almost complete destruction of their crystals. In addition, vacuolization of the cytoplasm, swelling of the mitochondria and distortion of their cristae were found. Incubation of the eosinophils with the antihistamine drug mepyramine, did not produce ultrastructural alterations.

Original languageEnglish
Pages (from-to)65-72
Number of pages8
Issue number1-2
StatePublished - 1975
Externally publishedYes


Dive into the research topics of 'Corticosteroid effect on eosinophils in vitro: ultrastructural studies'. Together they form a unique fingerprint.

Cite this