TY - JOUR
T1 - Cortical thickness in obsessive-compulsive disorder
T2 - Multisite mega-analysis of 780 brain scans from six centres
AU - Fouche, Jean Paul
AU - Du Plessis, Stefan
AU - Hattingh, Coenie
AU - Roos, Annerine
AU - Lochner, Christine
AU - Soriano-Mas, Carles
AU - Sato, Joao R.
AU - Nakamae, Takashi
AU - Nishida, Seiji
AU - Kwon, Jun Soo
AU - Jung, Wi Hoon
AU - Mataix-Cols, David
AU - Hoexter, Marcelo Q.
AU - Alonso, Pino
AU - De Wit, Stella J.
AU - Veltman, Dick J.
AU - Stein, Dan J.
AU - Van Den Heuvel, Odile A.
N1 - Publisher Copyright:
© The Royal College of Psychiatrists 2017.
PY - 2017/1
Y1 - 2017/1
N2 - Background There is accumulating evidence for the role of fronto-striatal and associated circuits in obsessive-compulsive disorder (OCD) but limited and conflicting data on alterations in cortical thickness. Aims To investigate alterations in cortical thickness and subcortical volume in OCD. Method In total, 412 patients with OCD and 368 healthy adults underwent magnetic resonance imaging scans. Betweengroup analysis of covariance of cortical thickness and subcortical volumes was performed and regression analyses undertaken. Results Significantly decreased cortical thickness was found in the OCD group compared with controls in the superior and inferior frontal, precentral, posterior cingulate, middle temporal, inferior parietal and precuneus gyri. There was also a group6age interaction in the parietal cortex, with increased thinning with age in the OCD group relative to controls. Conclusions Our findings are partially consistent with earlier work, suggesting that group differences in grey matter volume and cortical thickness could relate to the same underlying pathology of OCD. They partially support a frontostriatal model of OCD, but also suggest that limbic, temporal and parietal regions play a role in the pathophysiology of the disorder. The group6age interaction effects may be the result of altered neuroplasticity.
AB - Background There is accumulating evidence for the role of fronto-striatal and associated circuits in obsessive-compulsive disorder (OCD) but limited and conflicting data on alterations in cortical thickness. Aims To investigate alterations in cortical thickness and subcortical volume in OCD. Method In total, 412 patients with OCD and 368 healthy adults underwent magnetic resonance imaging scans. Betweengroup analysis of covariance of cortical thickness and subcortical volumes was performed and regression analyses undertaken. Results Significantly decreased cortical thickness was found in the OCD group compared with controls in the superior and inferior frontal, precentral, posterior cingulate, middle temporal, inferior parietal and precuneus gyri. There was also a group6age interaction in the parietal cortex, with increased thinning with age in the OCD group relative to controls. Conclusions Our findings are partially consistent with earlier work, suggesting that group differences in grey matter volume and cortical thickness could relate to the same underlying pathology of OCD. They partially support a frontostriatal model of OCD, but also suggest that limbic, temporal and parietal regions play a role in the pathophysiology of the disorder. The group6age interaction effects may be the result of altered neuroplasticity.
UR - http://www.scopus.com/inward/record.url?scp=85009121786&partnerID=8YFLogxK
U2 - 10.1192/bjp.bp.115.164020
DO - 10.1192/bjp.bp.115.164020
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C2 - 27198485
AN - SCOPUS:85009121786
SN - 0007-1250
VL - 210
SP - 67
EP - 74
JO - British Journal of Psychiatry
JF - British Journal of Psychiatry
IS - 1
ER -