Cortical localization of microbleeds in cerebral amyloid angiopathy: An ultra high-field 7T MRI study

Jun Ni, Eithan Auriel, Sergi Martinez-Ramirez, Boris Keil, Anne K. Reed, Panagiotis Fotiadis, Edip Mahmut Gurol, Steven M. Greenberg, Anand Viswanathan

Research output: Contribution to journalArticlepeer-review

Abstract

The extent of cortical involvement of cerebral amyloid angiopathy (CAA)-related microbleeds (CMBs) remains unclear. We examined five consecutive patients with probable CAA and three non-demented elderly subjects with ultra-high field 7T MRI, to identify the precise location of CAA-related CMBs. In five CAA patients, 169 of a total of 170 lobar CMBs were located in cortical areas on 7T MRI, while a precise cortical versus juxtacortical localization was unable to be determined for 50/76 CMBs observed by conventional MRI. 7T MRI demonstrates that nearly all lobar CMBs are located in cortex in CAA.

Original languageEnglish
Pages (from-to)1325-1330
Number of pages6
JournalJournal of Alzheimer's Disease
Volume43
Issue number4
DOIs
StatePublished - 2014
Externally publishedYes

Keywords

  • Cerebral amyloid angiopathy
  • cerebral microbleed
  • cortex
  • magnetic resonance imaging
  • ultra-high field

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