Cortical localization of microbleeds in cerebral amyloid angiopathy: An ultra high-field 7T MRI study

Jun Ni; Eithan Auriel; Sergi Martinez-Ramirez; Boris Keil; Anne K. Reed; Panagiotis Fotiadis; Edip Mahmut Gurol; Steven M. Greenberg; Anand Viswanathan

doi:10.3233/JAD-140864

Cortical localization of microbleeds in cerebral amyloid angiopathy: An ultra high-field 7T MRI study

Jun Ni, Eithan Auriel, Sergi Martinez-Ramirez, Boris Keil, Anne K. Reed, Panagiotis Fotiadis, Edip Mahmut Gurol, Steven M. Greenberg, Anand Viswanathan

Research output: Contribution to journal › Article › peer-review

Abstract

The extent of cortical involvement of cerebral amyloid angiopathy (CAA)-related microbleeds (CMBs) remains unclear. We examined five consecutive patients with probable CAA and three non-demented elderly subjects with ultra-high field 7T MRI, to identify the precise location of CAA-related CMBs. In five CAA patients, 169 of a total of 170 lobar CMBs were located in cortical areas on 7T MRI, while a precise cortical versus juxtacortical localization was unable to be determined for 50/76 CMBs observed by conventional MRI. 7T MRI demonstrates that nearly all lobar CMBs are located in cortex in CAA.

Original language	English
Pages (from-to)	1325-1330
Number of pages	6
Journal	Journal of Alzheimer's Disease
Volume	43
Issue number	4
DOIs	https://doi.org/10.3233/JAD-140864
State	Published - 2014
Externally published	Yes

Keywords

Cerebral amyloid angiopathy
cerebral microbleed
cortex
magnetic resonance imaging
ultra-high field

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10.3233/JAD-140864

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title = "Cortical localization of microbleeds in cerebral amyloid angiopathy: An ultra high-field 7T MRI study",

abstract = "The extent of cortical involvement of cerebral amyloid angiopathy (CAA)-related microbleeds (CMBs) remains unclear. We examined five consecutive patients with probable CAA and three non-demented elderly subjects with ultra-high field 7T MRI, to identify the precise location of CAA-related CMBs. In five CAA patients, 169 of a total of 170 lobar CMBs were located in cortical areas on 7T MRI, while a precise cortical versus juxtacortical localization was unable to be determined for 50/76 CMBs observed by conventional MRI. 7T MRI demonstrates that nearly all lobar CMBs are located in cortex in CAA.",

keywords = "Cerebral amyloid angiopathy, cerebral microbleed, cortex, magnetic resonance imaging, ultra-high field",

author = "Jun Ni and Eithan Auriel and Sergi Martinez-Ramirez and Boris Keil and Reed, {Anne K.} and Panagiotis Fotiadis and Gurol, {Edip Mahmut} and Greenberg, {Steven M.} and Anand Viswanathan",

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year = "2014",

doi = "10.3233/JAD-140864",

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T2 - An ultra high-field 7T MRI study

AU - Ni, Jun

AU - Auriel, Eithan

AU - Martinez-Ramirez, Sergi

AU - Keil, Boris

AU - Reed, Anne K.

AU - Fotiadis, Panagiotis

AU - Gurol, Edip Mahmut

AU - Greenberg, Steven M.

AU - Viswanathan, Anand

PY - 2014

Y1 - 2014

N2 - The extent of cortical involvement of cerebral amyloid angiopathy (CAA)-related microbleeds (CMBs) remains unclear. We examined five consecutive patients with probable CAA and three non-demented elderly subjects with ultra-high field 7T MRI, to identify the precise location of CAA-related CMBs. In five CAA patients, 169 of a total of 170 lobar CMBs were located in cortical areas on 7T MRI, while a precise cortical versus juxtacortical localization was unable to be determined for 50/76 CMBs observed by conventional MRI. 7T MRI demonstrates that nearly all lobar CMBs are located in cortex in CAA.

AB - The extent of cortical involvement of cerebral amyloid angiopathy (CAA)-related microbleeds (CMBs) remains unclear. We examined five consecutive patients with probable CAA and three non-demented elderly subjects with ultra-high field 7T MRI, to identify the precise location of CAA-related CMBs. In five CAA patients, 169 of a total of 170 lobar CMBs were located in cortical areas on 7T MRI, while a precise cortical versus juxtacortical localization was unable to be determined for 50/76 CMBs observed by conventional MRI. 7T MRI demonstrates that nearly all lobar CMBs are located in cortex in CAA.

KW - Cerebral amyloid angiopathy

KW - cerebral microbleed

KW - cortex

KW - magnetic resonance imaging

KW - ultra-high field

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Cortical localization of microbleeds in cerebral amyloid angiopathy: An ultra high-field 7T MRI study

Abstract

Keywords

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