Cortex-based inter-subject analysis of iEEG and fMRI data sets: Application to sustained task-related BOLD and gamma responses

Fabrizio Esposito*, Neomi Singer, Ilana Podlipsky, Itzhak Fried, Talma Hendler, Rainer Goebel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Linking regional metabolic changes with fluctuations in the local electromagnetic fields directly on the surface of the human cerebral cortex is of tremendous importance for a better understanding of detailed brain processes. Functional magnetic resonance imaging (fMRI) and intra-cranial electro-encephalography (iEEG) measure two technically unrelated but spatially and temporally complementary sets of functional descriptions of human brain activity. In order to allow fine-grained spatio-temporal human brain mapping at the population-level, an effective comparative framework for the cortex-based inter-subject analysis of iEEG and fMRI data sets is needed.We combined fMRI and iEEG recordings of the same patients with epilepsy during alternated intervals of passive movie viewing and music listening to explore the degree of local spatial correspondence and temporal coupling between blood oxygen level dependent (BOLD) fMRI changes and iEEG spectral power modulations across the cortical surface after cortex-based inter-subject alignment. To this purpose, we applied a simple model of the iEEG activity spread around each electrode location and the cortex-based inter-subject alignment procedure to transform discrete iEEG measurements into cortically distributed group patterns by establishing a fine anatomic correspondence of many iEEG cortical sites across multiple subjects.Our results demonstrate the feasibility of a multi-modal inter-subject cortex-based distributed analysis for combining iEEG and fMRI data sets acquired from multiple subjects with the same experimental paradigm but with different iEEG electrode coverage. The proposed iEEG-fMRI framework allows for improved group statistics in a common anatomical space and preserves the dynamic link between the temporal features of the two modalities.

Original languageEnglish
Pages (from-to)457-468
Number of pages12
JournalNeuroImage
Volume66
DOIs
StatePublished - 1 Feb 2013

Funding

FundersFunder number
Levie-Edersheim-Gitter Institute for Functional Brain Mapping
Seventh Framework Programme270460
European CommissionFP7-ICT-2009-270460
Israel Science FoundationISF-1747/07
Council for Higher Education

    Keywords

    • BOLD
    • Combined intra-cranial EEG-fMRI
    • Distributed source modeling
    • FMRI
    • Gamma
    • Intra-cranial EEG
    • Multi-modal imaging

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