Correlation between TPS and CEA in patients with colorectal cancer

B. Klein, I. Levin, M. Michaeli, L. R. Wolfson, R. Gal, I. Shapira, B. Kfir, E. Rakovsky, T. Klein

Research output: Contribution to journalArticlepeer-review


Serum TPS and CEA levels were measured in 173 cancer patients with various disease stages. The patients were divided into 4 groups: preoperative group, 16 patients in whom TPS and CEA were measured pre- and postoperatively; group I, 66 newly diagnosed patients up to 40 days post surgery; group II, 86 patients whose blood was taken 40-365 days post surgery, and group III, 47 patients on long-term follow-up in whom blood was taken more than one year after surgery. The median preoperative TPS levels were significantly higher (p < 0.01) than the postoperative levels. Patients with Dukes' D had significantly higher TPS (p < 0.01) and CEA levels as compared to patients with Dukes' B or C. For both Dukes' B and C stages there was a significant increase in median TPS level between group I and II and III. There was no similar increase in median CEA level. Serial measurements in individual patients show a significant increase in TPS levels between groups I, II and III. In Dukes' D patients, individual TPS levels decreased in response to therapy. There was a significant correlation between TPS and CEA levels. These results suggest that TPS measurement is additive to CEA in follow-up of asymptomatic patients, and to monitor response to therapy in patients with metastatic disease.

Original languageEnglish
Pages (from-to)267-271
Number of pages5
JournalInternational Journal of Oncology
Issue number2
StatePublished - 1995
Externally publishedYes


  • CEA
  • Colorectal cancer
  • TPS


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