Correlation between local cell membrane displacements and filterability of human red blood cells

Shmuel Tuvia, Shlomo Levin, Rafi Korenstein*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Local mechanical fluctuations of the cell membrane of human erythrocytes were shown to involve MgATP- and Mg2+-driven fast membrane displacements. We propose that these local bending deformations of the cell membrane are important for cell passage through capillaries. In order to verify this hypothesis, we examined cell membrane fluctuations and filterability of erythrocytes over a wide range of medium osmolalities (180-675 mosmol/kg H2O). The results indicate the existence of a positive correlation between the amplitude of local cell membrane displacements and cell filterability. We suggest that the occurrence of metabolically driven membrane displacements on the side surface of the red blood cell diminishes its bending stiffness and enables it to fold more efficiently upon entrance into blood capillaries. Thus, local cell membrane displacements seem to play an important role in microcirculation.

Original languageEnglish
Pages (from-to)32-36
Number of pages5
JournalFEBS Letters
Issue number1
StatePublished - 8 Jun 1992


  • Cell membrane fluctuation
  • Erythrocyte deformability
  • Erythrocyte filterability
  • Membrane curvature
  • Microcirculation
  • Osmosis


Dive into the research topics of 'Correlation between local cell membrane displacements and filterability of human red blood cells'. Together they form a unique fingerprint.

Cite this