TY - JOUR
T1 - Correction of Hyponatremia and Its Relation to Brain Damage
AU - Ellis, Simon J.
AU - Farfel, Zvi
AU - Pauzner, Rachel
AU - Mouallem, Meir
AU - Mayan, Haim
AU - Illowsky, Barbara P.
AU - Laureno, Robert
AU - Sterns, Richard H.
AU - Ayus, J. Carlos
AU - Krothapalli, Rhada K.
AU - Arieff, Allen I.
PY - 1988/5/19
Y1 - 1988/5/19
N2 - To the Editor: When prospective studies were called for to elucidate the role of serum sodium correction in the development of osmotic demyelination syndrome, a carefully designed prospective protocol comparing different rates of repair was envisaged,1 not the study reported by Ayus et al. (Nov. 5 issue).2 The design was flawed, in that Groups I (prospectively treated) and II (retrospectively analyzed) were not comparable. Details of the individual patient's rate of correction, underlying diagnosis, age, and sex were not given for Group I. The use of magnetic resonance imaging in only a minority of patients did not allow subclinical myelinolysis.
AB - To the Editor: When prospective studies were called for to elucidate the role of serum sodium correction in the development of osmotic demyelination syndrome, a carefully designed prospective protocol comparing different rates of repair was envisaged,1 not the study reported by Ayus et al. (Nov. 5 issue).2 The design was flawed, in that Groups I (prospectively treated) and II (retrospectively analyzed) were not comparable. Details of the individual patient's rate of correction, underlying diagnosis, age, and sex were not given for Group I. The use of magnetic resonance imaging in only a minority of patients did not allow subclinical myelinolysis.
UR - http://www.scopus.com/inward/record.url?scp=0023920890&partnerID=8YFLogxK
U2 - 10.1056/NEJM198805193182014
DO - 10.1056/NEJM198805193182014
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AN - SCOPUS:0023920890
SN - 0028-4793
VL - 318
SP - 1335
EP - 1337
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 20
ER -