Correction of Hyponatremia and Its Relation to Brain Damage

Simon J. Ellis, Zvi Farfel, Rachel Pauzner, Meir Mouallem, Haim Mayan, Barbara P. Illowsky, Robert Laureno, Richard H. Sterns, J. Carlos Ayus, Rhada K. Krothapalli, Allen I. Arieff

Research output: Contribution to journalLetterpeer-review


To the Editor: When prospective studies were called for to elucidate the role of serum sodium correction in the development of osmotic demyelination syndrome, a carefully designed prospective protocol comparing different rates of repair was envisaged,1 not the study reported by Ayus et al. (Nov. 5 issue).2 The design was flawed, in that Groups I (prospectively treated) and II (retrospectively analyzed) were not comparable. Details of the individual patient's rate of correction, underlying diagnosis, age, and sex were not given for Group I. The use of magnetic resonance imaging in only a minority of patients did not allow subclinical myelinolysis.

Original languageEnglish
Pages (from-to)1335-1337
Number of pages3
JournalNew England Journal of Medicine
Issue number20
StatePublished - 19 May 1988


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