Coronary risk factors in children of parents with premature coronary artery disease

Y. Beigel, J. George, L. Leibovici, A. Mattityahu, S. Sclarovsky, L. Blieden

Research output: Contribution to journalArticlepeer-review

Abstract

In order to assess the value of family history of premature coronary artery disease as a criterion for coronary risk factor screening, a group of 53 children with such a family history was selected. We determined various coronary risk factors in these children in comparison to 33 controls. Statistically significant differences were observed in apoprotein concentrations but not in concentrations of lipids, lipoproteins or glucose, or in blood pressure or body mass index. The ratio between apoprotein B and apoprotein A1 was the best discriminator between the two groups. The predictive value of family history is more reliable for detecting abnormal apoprotein ratio than for detection of hypercholestero‐lemia. We conclude that if abnormal apoprotein levels during childhood are found to be a valued predictor of premature coronary artery disease, then family history of premature coronary artery disease can be used to select children for determination and assessment of their coronary risk.

Original languageEnglish
Pages (from-to)162-165
Number of pages4
JournalActa Paediatrica, International Journal of Paediatrics
Volume82
Issue number2
DOIs
StatePublished - Feb 1993

Keywords

  • Apoproteins
  • coronary risk factors
  • hypercholesterolemia

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