Coronary artery calcification is associated with the development of hypertension

Chagai Grossman*, Joseph Shemesh, Zamir Dovrish, Nira Koren Morag, Shlomo Segev, Grossman Ehud

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background Hypertension (HTN) is associated with coronary artery calcification (CAC). We hypothesized that preexisting CAC is associated with the development of HTN. Methods This study included 483 normotensive subjects (mean age 54 years, 83% males) who underwent a baseline evaluation of their CAC score with ungated dual-section computed tomography during 2001-2002 and returned for at least the first annual follow-up. All subjects underwent an annual examination and were followed for a mean period of 6.6±3.2 years to identify newly developed HTN. Data on the patient's medical history, physical examination and laboratory evaluations were collected. Results During the follow-up, 104 subjects developed HTN. The rate of newly developed HTN was significantly higher among those with CAC (60 of 223 subjects; 27%) than among those without CAC (44 of 260; 17%) (P < 0.01). The presence of CAC predicted the development of HTN with a hazard ratio of 1.73 (95% confidence interval, 1.17-2.56; P < 0.01). After adjustment for age, sex, body mass index, smoking, baseline systolic blood pressure, and levels of glucose, triglycerides, and low-density lipoprotein cholesterol, the presence of CAC still predicted the development of HTN with a hazard ratio of 1.63 (95% confidence interval, 1.02-2.60; P = 0.04). Conclusion s Preexisting CAC is associated with the development of HTN.

Original languageEnglish
Pages (from-to)13-19
Number of pages7
JournalAmerican Journal of Hypertension
Volume26
Issue number1
DOIs
StatePublished - Jan 2013

Keywords

  • blood pressure
  • coronary artery calcifications
  • hypertension

Fingerprint

Dive into the research topics of 'Coronary artery calcification is associated with the development of hypertension'. Together they form a unique fingerprint.

Cite this