Corneal metastatic calcification in werner's syndrome

I. Kremer*, A. Ingber, I. Ben-Sira

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


We examined twin sisters with a clinical picture typical of Werner's syndrome. Both had undergone bilateral cataract extraction, one at 39 and one at 36 years of age, and had subsequently developed bilateral corneal metastatic calcification within a period of one to two years. In one twin, this keratopathy was associated with hypercalcemia. Each of the twins underwent penetrating keratoplasty in one eye, which was complicated by recurrence of metastatic calcification in a previously normal and clear corneal graft.

Original languageEnglish
Pages (from-to)221-226
Number of pages6
JournalAmerican Journal of Ophthalmology
Issue number2
StatePublished - 15 Aug 1988


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