TY - JOUR
T1 - Core-Shell Architecture in Poly(3-hexylthiophene) Nanoparticles
T2 - Tuning of the Photophysical Properties for Enhanced Neuronal Photostimulation
AU - Barsotti, Jonathan
AU - Perotto, Sara
AU - Candini, Andrea
AU - Colombo, Elisabetta
AU - Camargo, Franco V.A.
AU - Di Marco, Stefano
AU - Zangoli, Mattia
AU - Sardar, Samim
AU - Barker, Alex J.
AU - D’Andrea, Cosimo
AU - Cerullo, Giulio
AU - Rozen, Shlomo
AU - Benfenati, Fabio
AU - Di Maria, Francesca
AU - Lanzani, Guglielmo
N1 - Publisher Copyright:
© 2023 American Chemical Society.
PY - 2023/3/15
Y1 - 2023/3/15
N2 - This study shows that entirely thiophene-based core@shell nanoparticles, in which the shell is made of the oxidized form of the core polymer (P3HT@PTDOx NPs), result in a type II interface at the particle surface. This enables the development of advanced photon nanotransducers with unique chemical-physical and biofunctional properties due to the core@shell nanoarchitecture. We demonstrate that P3HT@PTDOx NPs present a different spatial localization of the excitation energy with respect to the nonoxidized NPs, showing a prevalence of surface states as a result of a different alignment of the HOMO/LUMO energy levels between the core and shell. This allows for the efficient photostimulation of retinal neurons. Indeed, thanks to the stronger and longer-lived charge separation, P3HT@PTDOx NPs, administered subretinally in degenerate retinas from the blind Royal College of Surgeons rats, are more effective in photostimulation of inner retinal neurons than the gold standard P3HT NPs.
AB - This study shows that entirely thiophene-based core@shell nanoparticles, in which the shell is made of the oxidized form of the core polymer (P3HT@PTDOx NPs), result in a type II interface at the particle surface. This enables the development of advanced photon nanotransducers with unique chemical-physical and biofunctional properties due to the core@shell nanoarchitecture. We demonstrate that P3HT@PTDOx NPs present a different spatial localization of the excitation energy with respect to the nonoxidized NPs, showing a prevalence of surface states as a result of a different alignment of the HOMO/LUMO energy levels between the core and shell. This allows for the efficient photostimulation of retinal neurons. Indeed, thanks to the stronger and longer-lived charge separation, P3HT@PTDOx NPs, administered subretinally in degenerate retinas from the blind Royal College of Surgeons rats, are more effective in photostimulation of inner retinal neurons than the gold standard P3HT NPs.
KW - KPFM
KW - conjugated polymers
KW - core@shell NPs
KW - degenerate retina
KW - neurons
KW - photophysical properties
KW - poly(3-hexylthiophene)
KW - time-resolved spectroscopy
UR - http://www.scopus.com/inward/record.url?scp=85149471044&partnerID=8YFLogxK
U2 - 10.1021/acsami.2c20640
DO - 10.1021/acsami.2c20640
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C2 - 36857156
AN - SCOPUS:85149471044
SN - 1944-8244
VL - 15
SP - 13472
EP - 13483
JO - ACS Applied Materials and Interfaces
JF - ACS Applied Materials and Interfaces
IS - 10
ER -