Core needle biopsy for diagnosing lymphoma in cervical lymphadenopathy: Meta-analysis

Anton Warshavsky; Roni Rosen; Chava Perry; Nidal Muhanna; Omer J. Ungar; Narin Nard Carmel-Neiderman; Dan M. Fliss; Gilad Horowitz

doi:10.1002/hed.26381

Core needle biopsy for diagnosing lymphoma in cervical lymphadenopathy: Meta-analysis

Anton Warshavsky, Roni Rosen, Chava Perry, Nidal Muhanna, Omer J. Ungar, Narin Nard Carmel-Neiderman, Dan M. Fliss, Gilad Horowitz^*

^*Corresponding author for this work

Tel Aviv University

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

Background: The diagnostic yield of core needle biopsies (CNB) in cervical lymphadenopathy for lymphoma diagnosis is controversial. The aim of this study was to calculate the accuracy of cervical CNB in diagnosing lymphoma. Methods: We conducted a meta-analysis of all studies on patients presenting with cervical lymphadenopathy and referred to CNB. Patients with a diagnosis other than lymphoma were excluded. All cases diagnosed with lymphoma sufficient to guide treatment based on CNB outcome were considered accurate (actionable) results. A separate meta-analysis was performed for various lymphoma subtypes. Results: Three prospective and 19 retrospective studies, comprising 1120 patients, met the inclusion criteria. The rate of actionable lymphoma diagnoses following CNB ranged from 30% to 96.3%, with a random-effects model of 82.45% (95% confidence interval [CI] =0.76-0.88) and a fixed-effects model of 78.3% (95% CI =0.75-0.80). Conclusion: CNB for cervical lymphadenopathy in lymphoma cases is relatively accurate in guiding treatment.

Original language	English
Pages (from-to)	3051-3060
Number of pages	10
Journal	Head and Neck
Volume	42
Issue number	10
DOIs	https://doi.org/10.1002/hed.26381
State	Published - 1 Oct 2020

Keywords

biopsy
cervical
core
lymphoma
meta-analysis

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10.1002/hed.26381

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title = "Core needle biopsy for diagnosing lymphoma in cervical lymphadenopathy: Meta-analysis",

abstract = "Background: The diagnostic yield of core needle biopsies (CNB) in cervical lymphadenopathy for lymphoma diagnosis is controversial. The aim of this study was to calculate the accuracy of cervical CNB in diagnosing lymphoma. Methods: We conducted a meta-analysis of all studies on patients presenting with cervical lymphadenopathy and referred to CNB. Patients with a diagnosis other than lymphoma were excluded. All cases diagnosed with lymphoma sufficient to guide treatment based on CNB outcome were considered accurate (actionable) results. A separate meta-analysis was performed for various lymphoma subtypes. Results: Three prospective and 19 retrospective studies, comprising 1120 patients, met the inclusion criteria. The rate of actionable lymphoma diagnoses following CNB ranged from 30% to 96.3%, with a random-effects model of 82.45% (95% confidence interval [CI] =0.76-0.88) and a fixed-effects model of 78.3% (95% CI =0.75-0.80). Conclusion: CNB for cervical lymphadenopathy in lymphoma cases is relatively accurate in guiding treatment.",

keywords = "biopsy, cervical, core, lymphoma, meta-analysis",

author = "Anton Warshavsky and Roni Rosen and Chava Perry and Nidal Muhanna and Ungar, {Omer J.} and Carmel-Neiderman, {Narin Nard} and Fliss, {Dan M.} and Gilad Horowitz",

note = "Publisher Copyright: {\textcopyright} 2020 Wiley Periodicals LLC",

year = "2020",

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doi = "10.1002/hed.26381",

language = "אנגלית",

volume = "42",

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T1 - Core needle biopsy for diagnosing lymphoma in cervical lymphadenopathy

T2 - Meta-analysis

AU - Warshavsky, Anton

AU - Rosen, Roni

AU - Perry, Chava

AU - Muhanna, Nidal

AU - Ungar, Omer J.

AU - Carmel-Neiderman, Narin Nard

AU - Fliss, Dan M.

AU - Horowitz, Gilad

PY - 2020/10/1

Y1 - 2020/10/1

N2 - Background: The diagnostic yield of core needle biopsies (CNB) in cervical lymphadenopathy for lymphoma diagnosis is controversial. The aim of this study was to calculate the accuracy of cervical CNB in diagnosing lymphoma. Methods: We conducted a meta-analysis of all studies on patients presenting with cervical lymphadenopathy and referred to CNB. Patients with a diagnosis other than lymphoma were excluded. All cases diagnosed with lymphoma sufficient to guide treatment based on CNB outcome were considered accurate (actionable) results. A separate meta-analysis was performed for various lymphoma subtypes. Results: Three prospective and 19 retrospective studies, comprising 1120 patients, met the inclusion criteria. The rate of actionable lymphoma diagnoses following CNB ranged from 30% to 96.3%, with a random-effects model of 82.45% (95% confidence interval [CI] =0.76-0.88) and a fixed-effects model of 78.3% (95% CI =0.75-0.80). Conclusion: CNB for cervical lymphadenopathy in lymphoma cases is relatively accurate in guiding treatment.

AB - Background: The diagnostic yield of core needle biopsies (CNB) in cervical lymphadenopathy for lymphoma diagnosis is controversial. The aim of this study was to calculate the accuracy of cervical CNB in diagnosing lymphoma. Methods: We conducted a meta-analysis of all studies on patients presenting with cervical lymphadenopathy and referred to CNB. Patients with a diagnosis other than lymphoma were excluded. All cases diagnosed with lymphoma sufficient to guide treatment based on CNB outcome were considered accurate (actionable) results. A separate meta-analysis was performed for various lymphoma subtypes. Results: Three prospective and 19 retrospective studies, comprising 1120 patients, met the inclusion criteria. The rate of actionable lymphoma diagnoses following CNB ranged from 30% to 96.3%, with a random-effects model of 82.45% (95% confidence interval [CI] =0.76-0.88) and a fixed-effects model of 78.3% (95% CI =0.75-0.80). Conclusion: CNB for cervical lymphadenopathy in lymphoma cases is relatively accurate in guiding treatment.

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KW - cervical

KW - core

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Core needle biopsy for diagnosing lymphoma in cervical lymphadenopathy: Meta-analysis

Abstract

Keywords

UN SDGs

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