TY - JOUR
T1 - Cooperativity of lectin binding to lymphocytes, and its relevance to mitogenic stimulation
AU - Prujansky, Aya
AU - Ravid, Amiram
AU - Sharon, Nathan
N1 - Funding Information:
This study was supportedin part by a grant from the LeukemiaR esearch FoundationN. .S. is an EstablishedIn vestigatoorf the Chief Scientist'Bs ureau, Israel Ministry of Health.
PY - 1978/3/21
Y1 - 1978/3/21
N2 - The relationship between the binding patterns of soybean agglutinin, peanut agglutinin (both in their native (unaggregated) form and in their polymerized form), and of Phaseolus vulgaris leucoagglutinin, to neuraminidase-treated lymphocytes from different sources, and the mitogenic activity of these lectins, was studied. In all cases investigated, binding of a lectin to lymphocytes which resulted in stimulation was a positive cooperative process. Our findings support the assumption that clustering of receptors and conformational changes in membrane structure are prerequisites for mitogenic stimulation.
AB - The relationship between the binding patterns of soybean agglutinin, peanut agglutinin (both in their native (unaggregated) form and in their polymerized form), and of Phaseolus vulgaris leucoagglutinin, to neuraminidase-treated lymphocytes from different sources, and the mitogenic activity of these lectins, was studied. In all cases investigated, binding of a lectin to lymphocytes which resulted in stimulation was a positive cooperative process. Our findings support the assumption that clustering of receptors and conformational changes in membrane structure are prerequisites for mitogenic stimulation.
UR - http://www.scopus.com/inward/record.url?scp=0017848245&partnerID=8YFLogxK
U2 - 10.1016/0005-2736(78)90195-5
DO - 10.1016/0005-2736(78)90195-5
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AN - SCOPUS:0017848245
SN - 0005-2736
VL - 508
SP - 137
EP - 146
JO - BBA - Biomembranes
JF - BBA - Biomembranes
IS - 1
ER -