TY - JOUR
T1 - Convulsant benzodiazepine Ro 5-3663 has anxiolytic properties
AU - Feldon, J.
AU - Myslobodsky, M.
N1 - Funding Information:
The technical assistance of R. Balamut and O. Kofman is gratefully acknowledged. We thank Hoffman-La Roche, Inc. for sending us a sample of Ro 5-3663. Partially supported by the Israel Commission for Basic Research (J. F.) and H. Pardee Foundation (M. M.).
PY - 1982/5
Y1 - 1982/5
N2 - A hypothesis was tested that convulsant benzodiazepine would have a pronounced pro-anxiety action. Contrary to expectation, convulsant benzodiazepine with GABA antagonistic properties, Ro 5-3663, administered alone (1 mg/kg, IP) or together with chlordiazepoxide (5 mg/kg, IP) antagonized response suppression in the one-trial inhibitory learning task.
AB - A hypothesis was tested that convulsant benzodiazepine would have a pronounced pro-anxiety action. Contrary to expectation, convulsant benzodiazepine with GABA antagonistic properties, Ro 5-3663, administered alone (1 mg/kg, IP) or together with chlordiazepoxide (5 mg/kg, IP) antagonized response suppression in the one-trial inhibitory learning task.
KW - Anxiety
KW - Convulsant benzodiazepine
KW - GABA
UR - http://www.scopus.com/inward/record.url?scp=0020064040&partnerID=8YFLogxK
U2 - 10.1016/0091-3057(82)90218-0
DO - 10.1016/0091-3057(82)90218-0
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AN - SCOPUS:0020064040
SN - 0091-3057
VL - 16
SP - 689
EP - 691
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
IS - 5
ER -