Conventional dose of omeprazole alters gastric flora

Y. Karmeli, R. Stalnikowitz, R. Eliakim, G. Rahav*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Quantitative cultures were carried out on samples from gastric juice obtained from 12 ambulatory patients with esophagitis before and one month after omeprazole therapy. An increase in the number of patients in whom gastric juice was culture-positive, as well as an increment in the bacterial counts were noted. The spectrum of microorganisms isolated from gastric juice was identical to the normal flora of the oral cavity, mainly α-hemolytic streptococci, corynebacteria, and Candida species. Thus, the counts of organisms within gastric contents are simply a reflection of swallowed oral, microflora that were able to survive due to the less acidic environment.

Original languageEnglish
Pages (from-to)2070-2073
Number of pages4
JournalDigestive Diseases and Sciences
Issue number9
StatePublished - Sep 1995
Externally publishedYes


  • gastric microorganism
  • gastric pH
  • omeprazole


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