Controlling the ribosomal density profile in mRNA translation

Yoram Zarai, Michael Margaliot, Eduardo D. Sontag, Tamir Tuller

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

During mRNA translation, the ribosomal density profile along the coding region of the mRNA molecule affects various fundamental intracellular phenomena. Thus, steering this profile from a given to a desired density is an important biological problem. This paper studies this problem using a dynamical model for mRNA translation, called the ribosome flow model (RFM), in which one views the transition rates along the mRNA molecule as controls.

Original languageEnglish
Title of host publication2016 IEEE 55th Conference on Decision and Control, CDC 2016
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages4184-4189
Number of pages6
ISBN (Electronic)9781509018376
DOIs
StatePublished - 27 Dec 2016
Event55th IEEE Conference on Decision and Control, CDC 2016 - Las Vegas, United States
Duration: 12 Dec 201614 Dec 2016

Publication series

Name2016 IEEE 55th Conference on Decision and Control, CDC 2016

Conference

Conference55th IEEE Conference on Decision and Control, CDC 2016
Country/TerritoryUnited States
CityLas Vegas
Period12/12/1614/12/16

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