TY - GEN
T1 - Controlling the ribosomal density profile in mRNA translation
AU - Zarai, Yoram
AU - Margaliot, Michael
AU - Sontag, Eduardo D.
AU - Tuller, Tamir
N1 - Publisher Copyright:
© 2016 IEEE.
PY - 2016/12/27
Y1 - 2016/12/27
N2 - During mRNA translation, the ribosomal density profile along the coding region of the mRNA molecule affects various fundamental intracellular phenomena. Thus, steering this profile from a given to a desired density is an important biological problem. This paper studies this problem using a dynamical model for mRNA translation, called the ribosome flow model (RFM), in which one views the transition rates along the mRNA molecule as controls.
AB - During mRNA translation, the ribosomal density profile along the coding region of the mRNA molecule affects various fundamental intracellular phenomena. Thus, steering this profile from a given to a desired density is an important biological problem. This paper studies this problem using a dynamical model for mRNA translation, called the ribosome flow model (RFM), in which one views the transition rates along the mRNA molecule as controls.
UR - http://www.scopus.com/inward/record.url?scp=85010800962&partnerID=8YFLogxK
U2 - 10.1109/CDC.2016.7798904
DO - 10.1109/CDC.2016.7798904
M3 - פרסום בספר כנס
AN - SCOPUS:85010800962
T3 - 2016 IEEE 55th Conference on Decision and Control, CDC 2016
SP - 4184
EP - 4189
BT - 2016 IEEE 55th Conference on Decision and Control, CDC 2016
PB - Institute of Electrical and Electronics Engineers Inc.
Y2 - 12 December 2016 through 14 December 2016
ER -