Controlling the ribosomal density profile in mRNA translation

Yoram Zarai; Michael Margaliot; Eduardo D. Sontag; Tamir Tuller

doi:10.1109/CDC.2016.7798904

Controlling the ribosomal density profile in mRNA translation

Yoram Zarai, Michael Margaliot, Eduardo D. Sontag, Tamir Tuller

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

During mRNA translation, the ribosomal density profile along the coding region of the mRNA molecule affects various fundamental intracellular phenomena. Thus, steering this profile from a given to a desired density is an important biological problem. This paper studies this problem using a dynamical model for mRNA translation, called the ribosome flow model (RFM), in which one views the transition rates along the mRNA molecule as controls.

Original language	English
Title of host publication	2016 IEEE 55th Conference on Decision and Control, CDC 2016
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	4184-4189
Number of pages	6
ISBN (Electronic)	9781509018376
DOIs	https://doi.org/10.1109/CDC.2016.7798904
State	Published - 27 Dec 2016
Event	55th IEEE Conference on Decision and Control, CDC 2016 - Las Vegas, United States Duration: 12 Dec 2016 → 14 Dec 2016

Publication series

Name	2016 IEEE 55th Conference on Decision and Control, CDC 2016

Conference

Conference	55th IEEE Conference on Decision and Control, CDC 2016
Country/Territory	United States
City	Las Vegas
Period	12/12/16 → 14/12/16

Access to Document

10.1109/CDC.2016.7798904

Cite this

Zarai, Y., Margaliot, M., Sontag, E. D., & Tuller, T. (2016). Controlling the ribosomal density profile in mRNA translation. In 2016 IEEE 55th Conference on Decision and Control, CDC 2016 (pp. 4184-4189). [7798904] (2016 IEEE 55th Conference on Decision and Control, CDC 2016). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/CDC.2016.7798904

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author = "Yoram Zarai and Michael Margaliot and Sontag, {Eduardo D.} and Tamir Tuller",

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Zarai, Y, Margaliot, M, Sontag, ED & Tuller, T 2016, Controlling the ribosomal density profile in mRNA translation. in 2016 IEEE 55th Conference on Decision and Control, CDC 2016., 7798904, 2016 IEEE 55th Conference on Decision and Control, CDC 2016, Institute of Electrical and Electronics Engineers Inc., pp. 4184-4189, 55th IEEE Conference on Decision and Control, CDC 2016, Las Vegas, United States, 12/12/16. https://doi.org/10.1109/CDC.2016.7798904

Controlling the ribosomal density profile in mRNA translation. / Zarai, Yoram; Margaliot, Michael; Sontag, Eduardo D. et al.

2016 IEEE 55th Conference on Decision and Control, CDC 2016. Institute of Electrical and Electronics Engineers Inc., 2016. p. 4184-4189 7798904 (2016 IEEE 55th Conference on Decision and Control, CDC 2016).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AB - During mRNA translation, the ribosomal density profile along the coding region of the mRNA molecule affects various fundamental intracellular phenomena. Thus, steering this profile from a given to a desired density is an important biological problem. This paper studies this problem using a dynamical model for mRNA translation, called the ribosome flow model (RFM), in which one views the transition rates along the mRNA molecule as controls.

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Controlling the ribosomal density profile in mRNA translation

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