Controlled trial of high spermatic vein ligation for varicocele in infertile men

I. Madgar, R. Weissenberg*, B. Lunenfeld, A. Karasik, B. Goldwasser

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

329 Scopus citations


Objective: To determine whether high ligation is an effective treatment for infertile men with clinical varicocele. Design: A randomized, controlled trial of high spermatic vein ligation was carried out. The patients were treated and observed for 3 years. Setting: Infertility treatment clinic and andrology laboratory in a hospital. Patients: Infertile men with abnormal semen analysis because of varicocele only. Intervention: High ligation 1 year postrecruitment (group A) and at the beginning of the study (group B). Results: Among the 20 couples in group A, 2 pregnancies (10%) were achieved within the 1st year of observation period. During the year after high ligation, there were 8 pregnancies (44.4%), and during the 2nd year after high ligation, there were 4 more pregnancies (22.2%). In group B, 15 pregnancies (60%) occurred within the 1st year after operation. Three pregnancies (12%) and 1 pregnancy (4%) occurred during the 2nd and 3rd year, respectively. After operation in all patients of both groups, there was significant improvement in semen parameters, regardless of pregnancy occurrence. The difference in pregnancy rate (PR) between the operated group B and nonoperated group A during the 1st year of study was found to be highly significant. Conclusions: It is concluded that in a population of infertile men presenting varicocele as the only demonstrable factor of infertility, the varicocele is clearly associated with infertility and reduced testicular function, and its correction by ligation improves sperm parameters and fertility rate. Furthermore, the highest PR in both groups occurred during the 1st year postoperation.

Original languageEnglish
Pages (from-to)120-124
Number of pages5
JournalFertility and Sterility
Issue number1
StatePublished - 1995
Externally publishedYes


  • Male infertility
  • fertility
  • high spermatic vein ligation
  • varicocele


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