Control of circularization of bacteriophage P1 DNA in Escherichia coli

N. Segev, G. Cohen

Research output: Contribution to journalArticlepeer-review

Abstract

Circularization of bacteriophage P1 DNA occurs during lytic infection in normal and recombination deficient strains, recA, recBC, recABC, of Escherichia coli. Circularization appears to be controlled by phage-specific recombination functions which are expressed both in lytic growth and from a P1 lysogen. Replication of the infecting genome is not essential for circularization. Kinetic studies on the synthesis of circular DNA in lytic infection in rec+ and recA hosts suggest that the bacterial general recombination system can act to ensure transition from an early circular mode of replication to another later mode.

Original languageEnglish
Pages (from-to)333-342
Number of pages10
JournalVirology
Volume114
Issue number2
DOIs
StatePublished - 31 Oct 1981

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