Control of circularization of bacteriophage P1 DNA in Escherichia coli

N. Segev; G. Cohen

doi:10.1016/0042-6822(81)90215-4

Control of circularization of bacteriophage P1 DNA in Escherichia coli

N. Segev, G. Cohen

Biotechnology

Research output: Contribution to journal › Article › peer-review

Abstract

Circularization of bacteriophage P1 DNA occurs during lytic infection in normal and recombination deficient strains, recA, recBC, recABC, of Escherichia coli. Circularization appears to be controlled by phage-specific recombination functions which are expressed both in lytic growth and from a P1 lysogen. Replication of the infecting genome is not essential for circularization. Kinetic studies on the synthesis of circular DNA in lytic infection in rec⁺ and recA hosts suggest that the bacterial general recombination system can act to ensure transition from an early circular mode of replication to another later mode.

Original language	English
Pages (from-to)	333-342
Number of pages	10
Journal	Virology
Volume	114
Issue number	2
DOIs	https://doi.org/10.1016/0042-6822(81)90215-4
State	Published - 31 Oct 1981

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AB - Circularization of bacteriophage P1 DNA occurs during lytic infection in normal and recombination deficient strains, recA, recBC, recABC, of Escherichia coli. Circularization appears to be controlled by phage-specific recombination functions which are expressed both in lytic growth and from a P1 lysogen. Replication of the infecting genome is not essential for circularization. Kinetic studies on the synthesis of circular DNA in lytic infection in rec+ and recA hosts suggest that the bacterial general recombination system can act to ensure transition from an early circular mode of replication to another later mode.

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Control of circularization of bacteriophage P1 DNA in Escherichia coli

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