Contributions of dendritic cells and macrophages to intestinal homeostasis and immune defense

Julia Farache, Ehud Zigmond, Guy Shakhar, Steffen Jung*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Intestinal mononuclear phagocytes have collectively emerged as key players in the maintenance of gut homeostasis, the development of gut inflammation and its resolution. Moreover, recent intense research efforts of many laboratories have revealed evidence for critical labor division between lamina propria-resident CD103 + dendritic cells and CX3CR1 + macrophages. In depth understanding of the respective activities of these cells in the mucosal landscape might pave the way for novel treatments of inflammatory bowel disorders (IBD).

Original languageEnglish
Pages (from-to)232-239
Number of pages8
JournalImmunology and Cell Biology
Volume91
Issue number3
DOIs
StatePublished - Mar 2013

Keywords

  • dendritic cells
  • homeostasis
  • inflammation
  • intestine
  • macrophages

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