Continuous wide-field characterization of drug release from skin substitute using off-axis interferometry

Haniel Gabai, Maya Baranes-Zeevi, Meital Zilberman, Natan T. Shaked

Research output: Contribution to journalArticlepeer-review

Abstract

We achieved continuous, noncontact wide-field imaging and characterization of drug release from a polymeric device in vitro by uniquely using off-axis interferometric imaging. Unlike the current gold-standard methods in this field, which are usually based on chromatography and spectroscopy, our method requires no user intervention during the experiment and involves less lab consumable instruments. Using a simplified interferometric imaging system, we experimentally demonstrate the characterization of anesthetic drug release (Bupivacaine) from a soy-based protein matrix, which is used as a skin substitute for wound dressing. Our results demonstrate the potential of interferometric imaging as an inexpensive and easy-to-use alternative for characterization of drug release in vitro.

Original languageEnglish
Pages (from-to)3017-3020
Number of pages4
JournalOptics Letters
Volume38
Issue number16
DOIs
StatePublished - 2013

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