Continuous Performance Test Is Sensitive to a Single Methylphenidate Challenge in Preschool Children With ADHD

Miriam Peskin*, Eliane Sommerfeld, Yael Basford, Shlomit Rozen, Gil Zalsman, Abraham Weizman, Iris Manor

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: There is a lack of evidence-based diagnostic paradigms and personalized interventions for preschoolers with ADHD. This study aimed to evaluate the performance of preschoolers diagnosed with ADHD on a continuous performance test (CPT) before and after a single methylphenidate (MPH) challenge. Method: The Test of Variables of Attention (TOVA)—a CPT—was administered to 61 preschoolers (5.64 ± 0.69 years; 74% boys) with ADHD before and after a single MPH challenge (0.3 or 0.5 mg/kg). Baseline TOVA performance was correlated with Conners’ Rating Scales (CRS) and compared with post-MPH TOVA performance. Results: A high rate of omission errors and several significant correlations between TOVA values and CRS scores were found at baseline. A single MPH administration improved TOVA performance significantly and was well tolerated. Conclusion: TOVA assessment may assist in the evaluation of the effect of MPH in preschoolers with ADHD and may help in planning interventions for them.

Original languageEnglish
Pages (from-to)226-234
Number of pages9
JournalJournal of Attention Disorders
Volume24
Issue number2
DOIs
StatePublished - 1 Jan 2020

Keywords

  • ADHD
  • continuous performance test
  • inattention
  • methylphenidate
  • preschoolers

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