Continuous intravenous epoprostenol in pulmonary hypertension: The Israel experience

Daniele Bendayan, Gershon Fink, Dan Aravot, Mordechai Ygla, Issahar Bendov, Leonard Bliden, Amiran Nir, Mordechai R. Kramer

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Primary idiopathic pulmonary hypertension is a rapidly progressive disease with a median survival of less than 3 years. Recently its prognosis was shown to dramatically improve with the use of epoprostenol, an arachidonic acid metabolite produced by the vascular endothelium, which increases the cardiac output and decreases the pulmonary vascular resistance and pulmonary arterial pressure. This drug enhances the quality of life, increases survival and delays or eliminates the need for transplantation. Objective: To review the experience of Israel hospitals with the use of epoprostenol. Methods: The study group comprised 13 patients, 5 men and 8 women, with an age range of 3-53 years. All patients suffered from arterial pulmonary hypertension. Epoprostenol was administered through a central line in an increased dose during the first 3 months, after which the dose was adjusted according to the clinical syndrome and the hemodynamic parameters. Results: After 3 months the mean dose was 10 ng/kg/min and the pulmonary artery pressure decreased from 7 to 38%. After one year, the PAP decreased at a slower rate. Two cases required transplantation, three patients died, and seven continued taking the drug (one of whom discontinued). Four episodes of septicemia were observed. Today 10 patients are alive and well and 7 continue to take epoprostenol. Conclusion: We found that epoprostenol improves survival, quality of life and hemodynamic parameters, with minimum side effects.

Original languageEnglish
Pages (from-to)255-258
Number of pages4
JournalIsrael Medical Association Journal
Volume4
Issue number4
StatePublished - 2002
Externally publishedYes

Keywords

  • Epoprostenol
  • Primary pulmonary hypertension
  • Pulmonary arterial pressure

Fingerprint

Dive into the research topics of 'Continuous intravenous epoprostenol in pulmonary hypertension: The Israel experience'. Together they form a unique fingerprint.

Cite this