Continuous administration of insulin-like growth factor-I and basic fibroblast growth factor does not affect left ventricular geometry after acute myocardial infarction in rats

M. Scheinowitz*, D. Abramov, A. Kotlyar, N. Savion, M. Eldar

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

We examined the long-term effect of exogenous administration of bFGF and IGF-I on myocardial geometry in 72 Sprague-Dawley male rats subjected to AMI. A preloaded miniature osmotic pump subsequently implanted in the peritoneum for continuous infusion (1 week) of IGF-I, bFGF, IGF-I+bFGF or rat albumin. Six weeks following AMI the rats were killed and cross-section slices were analyzed for left ventricular geometry. No differences were observed between IGF-I-treated, bFGF-treated, IGF-I+bFGF-treated and control groups in all parameters of the left ventricle.

Original languageEnglish
Pages (from-to)217-221
Number of pages5
JournalInternational Journal of Cardiology
Volume63
Issue number3
DOIs
StatePublished - 28 Feb 1998

Keywords

  • Left ventricular remodeling
  • Masson-trichrome stain slides
  • Morphometry

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