Context is everything: aneuploidy in cancer

Uri Ben-David*, Angelika Amon

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Cancer is driven by multiple types of genetic alterations, which range in size from point mutations to whole-chromosome gains and losses, known as aneuploidy. Chromosome instability, the process that gives rise to aneuploidy, can promote tumorigenesis by increasing genetic heterogeneity and promoting tumour evolution. However, much less is known about how aneuploidy itself contributes to tumour formation and progression. Unlike some pan-cancer oncogenes and tumour suppressor genes that drive transformation in virtually all cell types and cellular contexts, aneuploidy is not a universal promoter of tumorigenesis. Instead, recent studies suggest that aneuploidy is a context-dependent, cancer-type-specific oncogenic event that may have clinical relevance as a prognostic marker and as a potential therapeutic target.

Original languageEnglish
Pages (from-to)44-62
Number of pages19
JournalNature Reviews Genetics
Issue number1
StatePublished - 1 Jan 2020


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