Constructing the CF3 group; Unique trifluorodecarboxylation induced by BrF3

Revital Sasson, Shlomo Rozen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A variety of 2-alkyl-1,3-dithiane-2-carboxylic acids was prepared from the appropriate alkyl halides, 1,3-dithiane and CO2. These acids were reacted with BrF3 to form the trifluoromethylalkyl derivatives via a combination of ionic and radical trifluorodecarboxylation in about 50-60% yield.

Original languageEnglish
Pages (from-to)1083-1086
Number of pages4
JournalTetrahedron
Volume61
Issue number5
DOIs
StatePublished - 31 Jan 2005

Keywords

  • Bromine trifluoride
  • Dithiane
  • Trifluorodecarboxylation
  • Trifluoromethyl

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