Constant serum levels of secreted asialoglycoprotein receptor sH2a and decrease with cirrhosis

Ron Benyair, Maria Kondratyev, Elena Veselkin, Sandra Tolchinsky, Marina Shenkman, Yoav Lurie, Gerardo Z. Lederkremer

Research output: Contribution to journalArticlepeer-review

Abstract

AIM: To investigate the existence and levels of sH2a, a soluble secreted form of the asialoglycoprotein receptor in human serum.METHODS: Production of recombinant sH2a and development of a monoclonal antibody and an enzyme-linked immunosorbent assay (ELISA). This assay was used to determine the presence and concentration of sH2a in human sera of individuals of both sexes and a wide range of ages.RESULTS: The recombinant protein was produced successfully and a specifc ELISA assay was developed. The levels of sH2a in sera from 62 healthy individuals variedCONCLUSION: Constant sH2a levels suggest constitutive secretion from hepatocytes in healthy individuals. This constant level and the decrease with cirrhosis suggest a diagnostic potential.

Original languageEnglish
Pages (from-to)5305-5309
Number of pages5
JournalWorld Journal of Gastroenterology
Volume17
Issue number48
DOIs
StatePublished - 2011

Keywords

  • Asialoglycoprotein receptor
  • Cirrhosis
  • Hepatitis c virus
  • Liver diagnosis
  • Liver function

Fingerprint

Dive into the research topics of 'Constant serum levels of secreted asialoglycoprotein receptor sH2a and decrease with cirrhosis'. Together they form a unique fingerprint.

Cite this