Consistency checks to improve measurement with the Positive and Negative Syndrome Scale (PANSS)

ISCTM ALGORITHMS/FLAGS TO IDENTIFY CLINICAL INCONSISTENCY IN THE USE OF RATING SCALES IN CNS RCTs working group members

doi:10.1016/j.schres.2017.03.017

Consistency checks to improve measurement with the Positive and Negative Syndrome Scale (PANSS)

ISCTM ALGORITHMS/FLAGS TO IDENTIFY CLINICAL INCONSISTENCY IN THE USE OF RATING SCALES IN CNS RCTs working group members

Clinical Departments

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

International Society for CNS Clinical Trials and Methodology convened an expert working-group that assembled consistency/inconsistency flags for the Positive and Negative Syndrome Scale (PANSS). Twenty-four flags were identified and divided based on extent to which they represent error (Possibly, Probably, Very probably or definitely). The flags were applied to assessments derived from the NEWMEDS data repository and the CATIE clinical trial data. Almost 40% of ratings had at least one inconsistency flag raised and 10% had two. Application of flags to clinical rating can improve reliability and validity of trials.

Original language	English
Pages (from-to)	74-76
Number of pages	3
Journal	Schizophrenia Research
Volume	190
DOIs	https://doi.org/10.1016/j.schres.2017.03.017
State	Published - Dec 2017

Funding

Funders	Funder number
BiolineRX
Abraham Pharmaceuticals
Qatar National Research Fund
MHS Inc.
Les Laboratories Pierre Fabre
Seventh Framework Programme
Stanley Foundation
Eli Lilly and Company
National Institutes of Health
Roche
Servier
Pfizer
European Commission	115008
National Institute of Mental Health	R03MH106922
National Institute on Aging	K25AG051782

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10.1016/j.schres.2017.03.017

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title = "Consistency checks to improve measurement with the Positive and Negative Syndrome Scale (PANSS)",

abstract = "International Society for CNS Clinical Trials and Methodology convened an expert working-group that assembled consistency/inconsistency flags for the Positive and Negative Syndrome Scale (PANSS). Twenty-four flags were identified and divided based on extent to which they represent error (Possibly, Probably, Very probably or definitely). The flags were applied to assessments derived from the NEWMEDS data repository and the CATIE clinical trial data. Almost 40% of ratings had at least one inconsistency flag raised and 10% had two. Application of flags to clinical rating can improve reliability and validity of trials.",

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note = "Publisher Copyright: {\textcopyright} 2017 The Authors",

year = "2017",

month = dec,

doi = "10.1016/j.schres.2017.03.017",

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volume = "190",

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AU - ISCTM ALGORITHMS/FLAGS TO IDENTIFY CLINICAL INCONSISTENCY IN THE USE OF RATING SCALES IN CNS RCTs working group members

AU - Rabinowitz, Jonathan

AU - Schooler, Nina R.

AU - Anderson, Ariana

AU - Ayearst, Lindsay

AU - Daniel, David

AU - Davidson, Michael

AU - Khan, Anzalee

AU - Kinon, Bruce

AU - Menard, Francois

AU - Opler, Lewis

AU - Opler, Mark

AU - Severe, Joanne B.

AU - Williamson, David

AU - Yavorsky, Christian

AU - Zhao, Jun

PY - 2017/12

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Consistency checks to improve measurement with the Positive and Negative Syndrome Scale (PANSS)

Abstract

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