Considering parameter uncertainties in the design of safe processes

Mordechai Shacham*, Neima Brauner

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations


A systematic procedure has been developed for process unit design in order to meet the safety requirements even with the "worst case" combination of physical property values and other process variables, which are bounded within uncertainty limits. The new procedure can be implemented in widely available, general purpose mathematical software packages. The use of the proposed procedure is demonstrated by applying it to an example involving an exothermic reaction which is carried out in a cooled, semibatch reactor in order to estimate the minimal over-design of the cooling system required in order to prevent temperature runaway due to uncertainty of some of the physical properties and reaction rate coefficients.

Original languageEnglish
Title of host publicationComputer Aided Chemical Engineering
PublisherElsevier B.V.
Number of pages6
StatePublished - 2014

Publication series

NameComputer Aided Chemical Engineering
ISSN (Print)1570-7946


  • Bounded variables
  • Parameter uncertainty
  • Process design
  • Process safety


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