Consensus statement on the role of acute dopaminergic challenge in Parkinson's disease

Alberto Albanese*, Ubaldo Bonuccelli, Christine Brefel, K. Ray Chaudhuri, Carlo Colosimo, Tobias Eichhorn, Eldad Melamed, Pierre Pollak, Teus Van Laar, Mario Zappia

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Available evidence on the practice of acute pharmacological challenge tests in parkinsonian patients was reviewed by a committee of experts, which achieved a general consensus. The published data deal mainly with the acute administration of levodopa and apomorphine in Parkinson's disease. Such challenge may serve different purposes, e.g., research, diagnosis, or tailoring of treatment. Unique protocols describing the clinical setting and practice parameters are not available. The present paper describes the scientific back-ground and supplies practical guidelines, whenever possible, to perform and evaluate acute challenge tests in parkinsonian syndromes. With the appropriate indication and setting, acute challenge tests are useful in diagnosis and therapy of Parkinson's disease a related disorders.

Original languageEnglish
Pages (from-to)197-201
Number of pages5
JournalMovement Disorders
Issue number2
StatePublished - Mar 2001


  • Apomorphine
  • Diagnosis
  • Levodopa
  • Parkinson disease
  • Treatment


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