Consecutive controlled case series on effectiveness of opipramol in severe sleep bruxism management—preliminary study on new therapeutic path

Mieszko Wieckiewicz, Helena Martynowicz, Tomasz Wieczorek, Anna Wojakowska, Katarzyna Sluzalec-Wieckiewicz, Pawel Gac, Rafal Poreba, Grzegorz Mazur, Efraim Winocur, Joanna Smardz

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Sleep bruxism (SB) management aims to reduce the number and magnitude of bruxism episodes per hour of a patient’s sleep and, therefore, reduce the potentially negative clinical consequences. Opipramol belongs to the group of tricyclic antidepressants (TCAs) and is considered as an atypical TCA, as it acts primarily as a sigma receptor agonist. This study aimed to preliminarily determine the effectiveness of opipramol in the management of severe SB. Methods: A total of 19 otherwise healthy participants with severe SB diagnosed during stage I video polysomnography (vPSG) were subjected to an 8-week pharmacotherapy trial with a 100 mg bedtime daily dose of opipramol and were then analyzed by control stage II vPSG. Results: The participants included 14 females and 5 males, aged 20–47 years (mean ± standard deviation: 32.32 ± 8.12). A comparison of stage I and II vPSG recordings showed a decrease in all the studied SB parameters in 78.85% of participants. Only in a small group of participants (15.53%) was a non-significant increase of SB parameters observed. Conclusions: A single 100 mg dose of opipramol at bedtime seems to positively affect the reduction of SB in otherwise healthy individuals diagnosed with severe SB. However, the subject requires further research on a larger population including a control group.

Original languageEnglish
Article number146
Pages (from-to)1-14
Number of pages14
JournalBrain Sciences
Volume11
Issue number2
DOIs
StatePublished - Jan 2021

Keywords

  • Opipramol
  • Polysomnography
  • Sleep bruxism
  • Tricyclic antidepressants

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