TY - JOUR
T1 - Connectivity and expression in protein networks
T2 - Proteins in a complex are uniformly expressed
AU - Carmi, Shai
AU - Levanon, Erez Y.
AU - Havlin, Shlomo
AU - Eisenberg, Eli
PY - 2006
Y1 - 2006
N2 - We explore the interplay between the protein-protein interactions network and the expression of the interacting proteins. It is shown that interacting proteins are expressed in significantly more similar cellular concentrations. This is largely due to interacting pairs which are part of protein complexes. We solve a generic model of complex formation and show explicitly that complexes form most efficiently when their members have roughly the same concentrations. Therefore, the observed similarity in interacting protein concentrations could be attributed to optimization for efficiency of complex formation.
AB - We explore the interplay between the protein-protein interactions network and the expression of the interacting proteins. It is shown that interacting proteins are expressed in significantly more similar cellular concentrations. This is largely due to interacting pairs which are part of protein complexes. We solve a generic model of complex formation and show explicitly that complexes form most efficiently when their members have roughly the same concentrations. Therefore, the observed similarity in interacting protein concentrations could be attributed to optimization for efficiency of complex formation.
UR - http://www.scopus.com/inward/record.url?scp=33645012079&partnerID=8YFLogxK
U2 - 10.1103/PhysRevE.73.031909
DO - 10.1103/PhysRevE.73.031909
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C2 - 16605560
AN - SCOPUS:33645012079
SN - 1539-3755
VL - 73
JO - Physical Review E - Statistical, Nonlinear, and Soft Matter Physics
JF - Physical Review E - Statistical, Nonlinear, and Soft Matter Physics
IS - 3
M1 - 031909
ER -