Congenital Mirror Movements Associated With Brain Malformations

Andreea Nissenkorn, Keren Yosovich, Zvi Leibovitz, Tamar Gur Hartman, Itay Zelcer, Mohammad Hugirat, Dorit Lev, Tally Lerman-Sagie, Lubov Blumkin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: Congenital mirror movements are involuntary movements of a side of the body imitating intentional movements on the opposite side, appearing in early childhood and persisting beyond 7 years of age. Congenital mirror movements are usually idiopathic but have been reported in association with various brain malformations. Methods: We describe clinical, genetic, and radiologic features in 9 individuals from 5 families manifesting congenital mirror movements. Results: The brain malformations associated with congenital mirror movements were: dysplastic corpus callosum in father and daughter with a heterozygous p.Met1* mutation in DCC; hypoplastic corpus callosum, dysgyria, and malformed vermis in a mother and son with a heterozygous p.Thr312Met mutation in TUBB3; dysplastic corpus callosum, dysgyria, abnormal vermis, and asymmetric ventricles in a father and 2 daughters with a heterozygous p.Arg121Trp mutation in TUBB; hypoplastic corpus callosum, dysgyria, malformed basal ganglia and abnormal vermis in a patient with a heterozygous p.Glu155Asp mutation in TUBA1A; hydrocephalus, hypoplastic corpus callosum, polymicrogyria, and cerebellar cysts in a patient with a homozygous p.Pro312Leu mutation in POMGNT1. Conclusion: DCC, TUBB3, TUBB, TUBA1A, POMGNT1 cause abnormal axonal guidance via different mechanisms and result in congenital mirror movements associated with brain malformations.

Original languageEnglish
Pages (from-to)545-555
Number of pages11
JournalJournal of Child Neurology
Issue number7
StatePublished - Jun 2021


  • DCC
  • TUBA1A
  • TUBB
  • TUBB3
  • congenital mirror movements
  • corpus callosum


Dive into the research topics of 'Congenital Mirror Movements Associated With Brain Malformations'. Together they form a unique fingerprint.

Cite this