Congenital bilateral absence of vas deferens in the absence of cystic fibrosis

A. Augarten, Y. Yahav, J. Laufer, A. Szeinberg, J. Dor, S. Mashiach, I. Madgar, D. Halle, E. Gazit, B. S. Kerem

Research output: Contribution to journalArticlepeer-review

Abstract

The high frequency of mutations in the cystic fibrosis gene in patients with congenital bilateral absence of vas deferens (CBAVD) has raised the question whether all of them have a genital form of cystic fibrosis. We investigated 47 CBAVD patients by ultrasonography, 10 (21%) had renal malformations and 37 (79%) did not. In the former group, no cystic fibrosis mutations were found and sweat chloride concentrations were normal. In the latter group, 18 patients (49%) carried at least one cystic fibrosis mutation and sweat chloride was high in 17 of 26 tested (65%). Our findings suggest that CBAVD patients with renal malformations do not necessarily have cystic fibrosis.

Original languageEnglish
Pages (from-to)1473-1474
Number of pages2
JournalThe Lancet
Volume344
Issue number8935
DOIs
StatePublished - 26 Nov 1994
Externally publishedYes

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