TY - JOUR
T1 - Conflict monitoring mechanism at the single-neuron level in the human ventral anterior cingulate cortex
AU - Shapira-Lichter, Irit
AU - Strauss, Ido
AU - Oren, Noga
AU - Gazit, Tomer
AU - Sammartino, Francesco
AU - Giacobbe, Peter
AU - Kennedy, Sidney
AU - Hutchison, William D.
AU - Fried, Itzhak
AU - Hendler, Talma
AU - Lozano, Andres M.
N1 - Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/7/15
Y1 - 2018/7/15
N2 - Life requires monitoring and adjusting behavior in the face of conflicts. The conflict monitoring theory implicates the anterior cingulate cortex (ACC) in these processes; its ventral aspect (vACC) specializes in emotional conflict. To elucidate the underpinning neural mechanism, we recorded vACC extracellular activity from 12 patients with mood disorders or epilepsy who performed the face-emotional Stroop task. Behaviorally, both conflict detection and adaptation to conflict were evident. The firing rate of neurons in the vACC represented current conflict, i.e., current-congruency. The late onset of the effect is compatible with a role in monitoring. Additionally, early responses of some neurons represented the immediate history of conflicts, i.e., previous-trial-congruency. Finally, in some neurons the response to the current-trial was modulated by previous-trial-congruency, laying the ground for adjusting-to-conflicts. Our results uncover a single neuron level mechanism in the vACC that encodes and integrates past and present emotional conflicts, allowing humans to accommodate their responses accordingly.
AB - Life requires monitoring and adjusting behavior in the face of conflicts. The conflict monitoring theory implicates the anterior cingulate cortex (ACC) in these processes; its ventral aspect (vACC) specializes in emotional conflict. To elucidate the underpinning neural mechanism, we recorded vACC extracellular activity from 12 patients with mood disorders or epilepsy who performed the face-emotional Stroop task. Behaviorally, both conflict detection and adaptation to conflict were evident. The firing rate of neurons in the vACC represented current conflict, i.e., current-congruency. The late onset of the effect is compatible with a role in monitoring. Additionally, early responses of some neurons represented the immediate history of conflicts, i.e., previous-trial-congruency. Finally, in some neurons the response to the current-trial was modulated by previous-trial-congruency, laying the ground for adjusting-to-conflicts. Our results uncover a single neuron level mechanism in the vACC that encodes and integrates past and present emotional conflicts, allowing humans to accommodate their responses accordingly.
UR - http://www.scopus.com/inward/record.url?scp=85044779890&partnerID=8YFLogxK
U2 - 10.1016/j.neuroimage.2018.03.028
DO - 10.1016/j.neuroimage.2018.03.028
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C2 - 29551460
AN - SCOPUS:85044779890
SN - 1053-8119
VL - 175
SP - 45
EP - 55
JO - NeuroImage
JF - NeuroImage
ER -