TY - JOUR
T1 - Confirmation and dissection of QTL controlling resistance to malaria in mice
AU - Hernandez-Valladares, Maria
AU - Naessens, Jan
AU - Gibson, John P.
AU - Musoke, Anthony J.
AU - Nagda, Sonal
AU - Rihet, Pascal
AU - Ole-MoiYoi, Onesmo K.
AU - Iraqi, Fuad A.
PY - 2004/5
Y1 - 2004/5
N2 - We developed an F11 AIL population from an F1 cross of A/J (susceptible) and C57BL/6J (resistant) mouse strains. One thousand F 11 mice were challenged with P.c. chabaudi 54X, and 340 mice selected from the phenotypic extremes for susceptibility and resistance were genotyped for microsatellite markers on Chromosomes (Chrs) 5, 8, and 17. QTL originally detected in backcross and F2 populations were confirmed on the three chromosomes within narrower genomic regions, by maximum likelihood and regression analyses. Each of the previously mapped QTL on Chrs 5 and 17 resolved into two linked QTLs. The distal and proximal QTLs on Chrs 5 and 17, respectively, map to the previously reported QTL.
AB - We developed an F11 AIL population from an F1 cross of A/J (susceptible) and C57BL/6J (resistant) mouse strains. One thousand F 11 mice were challenged with P.c. chabaudi 54X, and 340 mice selected from the phenotypic extremes for susceptibility and resistance were genotyped for microsatellite markers on Chromosomes (Chrs) 5, 8, and 17. QTL originally detected in backcross and F2 populations were confirmed on the three chromosomes within narrower genomic regions, by maximum likelihood and regression analyses. Each of the previously mapped QTL on Chrs 5 and 17 resolved into two linked QTLs. The distal and proximal QTLs on Chrs 5 and 17, respectively, map to the previously reported QTL.
UR - http://www.scopus.com/inward/record.url?scp=2342520650&partnerID=8YFLogxK
U2 - 10.1007/s00335-004-3042-4
DO - 10.1007/s00335-004-3042-4
M3 - מאמר
AN - SCOPUS:2342520650
VL - 15
SP - 390
EP - 398
JO - Mammalian Genome
JF - Mammalian Genome
SN - 0938-8990
IS - 5
ER -
