Confirmation and dissection of QTL controlling resistance to malaria in mice

Maria Hernandez-Valladares, Jan Naessens, John P. Gibson, Anthony J. Musoke, Sonal Nagda, Pascal Rihet, Onesmo K. Ole-MoiYoi, Fuad A. Iraqi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

We developed an F11 AIL population from an F1 cross of A/J (susceptible) and C57BL/6J (resistant) mouse strains. One thousand F 11 mice were challenged with P.c. chabaudi 54X, and 340 mice selected from the phenotypic extremes for susceptibility and resistance were genotyped for microsatellite markers on Chromosomes (Chrs) 5, 8, and 17. QTL originally detected in backcross and F2 populations were confirmed on the three chromosomes within narrower genomic regions, by maximum likelihood and regression analyses. Each of the previously mapped QTL on Chrs 5 and 17 resolved into two linked QTLs. The distal and proximal QTLs on Chrs 5 and 17, respectively, map to the previously reported QTL.

Original languageEnglish
Pages (from-to)390-398
Number of pages9
JournalMammalian Genome
Volume15
Issue number5
DOIs
StatePublished - May 2004
Externally publishedYes

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