Confidence Intervals and Simultaneous Confidence Bands Based on Deep Learning

Deep learning models have significantly improved prediction accuracy in various fields, gain-ing recognition across numerous disciplines. Yet, an aspect of deep learning that remains insufficiently addressed is the assessment of prediction uncertainty. Producing reliable uncertainty estimators could be crucial in practical terms. For instance, predictions associated with a high degree of uncertainty could be sent for further evaluation. Recent works in uncertainty quantification of deep learning predictions, including Bayesian posterior credible intervals and a frequentist confidence-interval estimation, have proven to yield either invalid or overly conservative intervals. Furthermore, there is currently no method for quantifying uncertainty that can accommodate deep neural networks for survival (time-to-event) data that involves right-censored outcomes. In this work, we provide a non-parametric bootstrap method that disentangles data uncertainty from the noise inherent in the adopted optimization algorithm. The validity of the proposed approach is demonstrated through an extensive simulation study, which shows that the method is accurate (i.e., valid and not overly con-servative) as long as the network is sufficiently deep to ensure that the estimators provided by the deep neural network exhibit minimal bias. Otherwise, undercoverage of up to 8% is observed. The proposed ad-hoc method can be easily integrated into any deep neural network without interfering with the training process. The utility of the proposed approach is demonstrated through two applications: constructing simultaneous confidence bands for survival curves generated by deep neural networks dealing with right-censored survival data, and constructing a confidence interval for classification probabilities in the context of binary classification regression. Code for the data analysis and reported simulation is available at Githubsite: https://github.com/Asafba123/Survival_bootstrap.