Concomitant regulation of T-cell activation and homeostasis

Zvi Grossman*, Booki Min, Martin Meier-Schellersheim, William E. Paul

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


T cells constitute a heterogeneous, hierarchically organized population, comprising several maturation/differentiation states that have different capacities for clonal expansion and self-renewal. Here, we argue that the relative probabilities of proliferation, differentiation and death - the cellular events that determine the population's structure, as well as its size - are not entirely preprogrammed or fixed; instead, these events are regulated dynamically through the recurrent interaction of lymphocytes with exogenous and endogenous antigens, antigen-presenting cells and each other.

Original languageEnglish
Pages (from-to)387-395
Number of pages9
JournalNature Reviews Immunology
Issue number5
StatePublished - May 2004


FundersFunder number
National Institute of Allergy and Infectious DiseasesZIAAI000926


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