Concomitant administration of isradipine and spirapril prevents reduction of renal function induced by acute administration of spirapril in patients with reduced renal function

C. Wittenberg, A. Erman, J. Shohat, G. Boner

Research output: Contribution to journalArticlepeer-review

Abstract

Angiotensin-converting enzyme (ACE) inhibitors may cause a further decrease in renal function in patients who already have renal failure. The acute effects of the ACE inhibitor spirapril on renal function were investigated in 10 patients with mild-to-moderate renal failure (serum creatinine of 1.5-2.5 mg/dl). Acute oral administration of spirapril at 6 mg resulted in decreases in inulin clearance (from 53.7 ± 12.8 to 44.6 ± 8.8 ml/min; p < 0.02; n = 5) and in PAH clearances (from 215 ± 141.9 to 184 ± 37.8 ml/min; p < 0.006; n = 5). However, when the acute administration of 6 mg of spirapril was given concomitantly with isradipine at 5 mg, there were no changes in these renal function parameters.

Original languageEnglish
Pages (from-to)48-49
Number of pages2
JournalBlood Pressure, Supplement
Volume3
Issue number1
StatePublished - 1994

Keywords

  • hypertension
  • isradipine
  • renal function
  • spirapril

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