Conceptual changes in ameloblastoma: Suggested re-classification of a "veteran" tumor

Ayelet Zlotogorski-Hurvitz, Merva Soluk Tekkeşin, Fabricio Passador-Santos, Victor Angelo Martins Montalli, Tuula Salo, Matti Mauramo, Lazar Kats, Amos Buchner, Marilena Vered*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objectives: The merging of ameloblastoma (AM) with mural unicystic ameloblastoma (UAM-M) was suggested by the 2017 WHO based on similar treatment needs. In an international multicenter study, we investigated the characteristics of their merged product (merged-AM) and raised the possibility of unifying AM and UAM (total-AM). Materials and methods: AM and UAM (luminal/intraluminal/mural), separate and combined, were analyzed for demographic/clinical/radiological features. ANOVA and chi-square tests were followed by univariate and multivariate analyses, and significance was set at p <.05. Results: The patients’ mean age was 39.6 ± 20.3 years in merged-AM (147 AM, 76 UAM-M), 45.1 ± 19.4 years in AM (p =.009). Merged-AM comprised 51.3% multilocular/48.7% unilocular tumors, AM comprised 72.5%/27.5%, respectively (p <.001). Merged-AM was associated with impacted teeth in 30.8%, AM in 18% (p =.023). The probability of merged-AM for multilocularity increased by 2.4% per year of age (95%CI 0.6–4.2, p =.009). Association with impacted teeth decreased by 7.9% per year of age (95%CI 1.9–14.39, p =.009). Merged-AM did not differ from total-AM (p >.05). Conclusions: Merged-AM partially differed from AM, but differences appeared to diminish in an age/time-wise manner. Merged-AM and total-AM were nearly indistinguishable. Therefore, AM and UAM may be considered a continuous spectrum of one type of tumor, further necessitating revision of the treatment approaches.

Original languageEnglish
Pages (from-to)703-710
Number of pages8
JournalOral Diseases
Issue number3
StatePublished - Apr 2022


  • ameloblastoma
  • characteristics
  • classification


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