TY - GEN
T1 - Conceptual and methodological biases in network models
AU - Lamm, Ehud
PY - 2009
Y1 - 2009
N2 - Many natural and biological phenomena can be depicted as networks. Theoretical and empirical analyses of networks have become prevalent. I discuss theoretical biases involved in the delineation of biological networks. The network perspective is shown to dissolve the distinction between regulatory architecture and regulatory state, consistent with the theoretical impossibility of distinguishing a priori between "program" and "data." The evolutionary significance of the dynamics of trans-generational and interorganism regulatory networks is explored and implications are presented for understanding the evolution of the biological categories development-heredity, plasticity-evolvability, and epigenetic-genetic.
AB - Many natural and biological phenomena can be depicted as networks. Theoretical and empirical analyses of networks have become prevalent. I discuss theoretical biases involved in the delineation of biological networks. The network perspective is shown to dissolve the distinction between regulatory architecture and regulatory state, consistent with the theoretical impossibility of distinguishing a priori between "program" and "data." The evolutionary significance of the dynamics of trans-generational and interorganism regulatory networks is explored and implications are presented for understanding the evolution of the biological categories development-heredity, plasticity-evolvability, and epigenetic-genetic.
KW - Epigenetic inheritance
KW - Evo-devo
KW - Evolutionary transitions
KW - Variation
KW - Weak linkage
UR - http://www.scopus.com/inward/record.url?scp=70350444934&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2009.05009.x
DO - 10.1111/j.1749-6632.2009.05009.x
M3 - ???researchoutput.researchoutputtypes.contributiontobookanthology.conference???
C2 - 19845645
AN - SCOPUS:70350444934
SN - 9781573317658
T3 - Annals of the New York Academy of Sciences
SP - 291
EP - 304
BT - Natural Genetic Engineering and Natural Genome Editing
PB - Blackwell Publishing Inc.
ER -