Concentration of ofloxacin and ciprofloxacin in human semen following a single oral dose

S. A. Berger; H. Yavetz; G. Paz; A. Gorea; Z. Homonnai

doi:10.1016/S0022-5347(17)39554-X

Concentration of ofloxacin and ciprofloxacin in human semen following a single oral dose

S. A. Berger^*, H. Yavetz, G. Paz, A. Gorea, Z. Homonnai

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

A single oral dose of ofloxacin (400 mg.) or ciprofloxacin (500 mg.) was administered to each of 40 men. The mean concentrations of ofloxacin in semen exceeded those of ciprofloxacin at 1 hour (p = 0.035) and 24 hours (p = 0.028), while the levels of the 2 drugs at 2 and 4 hours were comparable. Semen concentrations of ofloxacin but not ciprofloxacin exceeded the reported minimal inhibitory concentration of Enterobacteriaceae, Chlamydia trachomatis and genital Mycoplasma species 24 hours after dosage.

Original language	English
Pages (from-to)	683-684
Number of pages	2
Journal	Journal of Urology
Volume	144
Issue number	3
DOIs	https://doi.org/10.1016/S0022-5347(17)39554-X
State	Published - 1990
Externally published	Yes

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title = "Concentration of ofloxacin and ciprofloxacin in human semen following a single oral dose",

abstract = "A single oral dose of ofloxacin (400 mg.) or ciprofloxacin (500 mg.) was administered to each of 40 men. The mean concentrations of ofloxacin in semen exceeded those of ciprofloxacin at 1 hour (p = 0.035) and 24 hours (p = 0.028), while the levels of the 2 drugs at 2 and 4 hours were comparable. Semen concentrations of ofloxacin but not ciprofloxacin exceeded the reported minimal inhibitory concentration of Enterobacteriaceae, Chlamydia trachomatis and genital Mycoplasma species 24 hours after dosage.",

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AB - A single oral dose of ofloxacin (400 mg.) or ciprofloxacin (500 mg.) was administered to each of 40 men. The mean concentrations of ofloxacin in semen exceeded those of ciprofloxacin at 1 hour (p = 0.035) and 24 hours (p = 0.028), while the levels of the 2 drugs at 2 and 4 hours were comparable. Semen concentrations of ofloxacin but not ciprofloxacin exceeded the reported minimal inhibitory concentration of Enterobacteriaceae, Chlamydia trachomatis and genital Mycoplasma species 24 hours after dosage.

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Concentration of ofloxacin and ciprofloxacin in human semen following a single oral dose

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