Concentration of ofloxacin and ciprofloxacin in human semen following a single oral dose

S. A. Berger, H. Yavetz, G. Paz, A. Gorea, Z. Homonnai

Research output: Contribution to journalArticlepeer-review

Abstract

A single oral dose of ofloxacin (400 mg.) or ciprofloxacin (500 mg.) was administered to each of 40 men. The mean concentrations of ofloxacin in semen exceeded those of ciprofloxacin at 1 hour (p = 0.035) and 24 hours (p = 0.028), while the levels of the 2 drugs at 2 and 4 hours were comparable. Semen concentrations of ofloxacin but not ciprofloxacin exceeded the reported minimal inhibitory concentration of Enterobacteriaceae, Chlamydia trachomatis and genital Mycoplasma species 24 hours after dosage.

Original languageEnglish
Pages (from-to)683-684
Number of pages2
JournalJournal of Urology
Volume144
Issue number3
DOIs
StatePublished - 1990
Externally publishedYes

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