Computer simulation of the mechanically-assisted failing canine circulation

Ofer Barnea, Thomas W. Moore, Dov Jaron*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

A model of the cardiovascular system is presented. The model includes representations of the left and right ventricles, a nonlinear multielement model of the aorta and its main branches, and lumped models of the systemic veins and the pulmonary circulation. A simulation of the intra-aortic balloon pump and representations of physiological compensatory mechanisms are also incorporated in the model. Parameters of the left ventricular model were set to simulate either the normal or failing canine circulation. Pressure and flow waveforms throughout the circulation as well as ventricular pressure and volume were calculated for the normal, failing, and assisted failing circulation. Cardiac oxygen supply and consumption were calculated from the model. They were used as direct indices of cardiac energy supply and utilization to assess the effects of cardiac assistance.

Original languageEnglish
Pages (from-to)263-283
Number of pages21
JournalAnnals of Biomedical Engineering
Volume18
Issue number3
DOIs
StatePublished - May 1990

Keywords

  • Cardiac assist
  • Cardiovascular
  • Energy balance
  • Intra-aortic balloon
  • Model simulation

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