Computational normal mode analysis accurately replicates the activity and specificity profiles of CRISPR-Cas9 and high-fidelity variants

Keyphrases

• Cas9 Protein 100%
• Normal Mode Analysis 100%
• Guide RNA (gRNA) 100%
• Clinical Trials 33%
• Enzymatic Activity 33%
• Disease-causing mutations 33%
• Genetic Engineering 33%
• CRISPR-Cas System 33%
• Machine Learning Algorithms 33%
• Design Principles 33%
• Design Machines 33%
• Target DNA 33%
• Gene Editing 33%
• Cas Proteins 33%
• Targeting Efficacy 33%
• Principle Learning 33%
• Engineered Cas9 33%
• SpyCas9 33%
• Cas9 Variants 33%
• Reference Genome 33%
• Algorithm-based 33%
• Exact Structures 33%
• SgRNA Design 33%

Biochemistry, Genetics and Molecular Biology

• Guide RNA 100%
• CRISPR/Cas9 100%
• Enzyme 33%
• Enzyme Activity 33%
• Clinical Trial 33%
• CRISPR Cas System 33%
• Genome Editing 33%
• Cas9 33%
• Cas9 Protein 33%
• Reference Genome 33%