Compulsivity is linked to reduced adolescent development of goal-directed control and frontostriatal functional connectivity

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22 Scopus citations

Abstract

A characteristic of adaptive behavior is its goal-directed nature. An ability to act in a goal-directed manner is progressively refined during development, but this refinement can be impacted by the emergence of psychiatric disorders. Disorders of compulsivity have been framed computationally as a deficit in model-based control, and have been linked also to abnormal frontostriatal connectivity. However, the developmental trajectory of model-based control, including an interplay between its maturation and an emergence of compulsivity, has not been characterized. Availing of a large sample of healthy adolescents (n = 569) aged 14 to 24 y, we show behaviorally that over the course of adolescence there is a withinperson increase in model-based control, and this is more pronounced in younger participants. Using a bivariate latent change score model, we provide evidence that the presence of higher compulsivity traits is associated with an atypical profile of this developmental maturation in model-based control. Resting-state fMRI data from a subset of the behaviorally assessed subjects (n = 230) revealed that compulsivity is associated with a less pronounced change of within-subject developmental remodeling of functional connectivity, specifically between the striatum and a frontoparietal network. Thus, in an otherwise clinically healthy population sample, in early development, individual differences in compulsivity are linked to the developmental trajectory of model-based control and a remodeling of frontostriatal connectivity.

Original languageEnglish
Pages (from-to)25911-25922
Number of pages12
JournalProceedings of the National Academy of Sciences of the United States of America
Volume117
Issue number41
DOIs
StatePublished - 13 Oct 2020
Externally publishedYes

Funding

FundersFunder number
Gates Cambridge Trust
National Institute for Health Research
Max-Planck-Gesellschaft
UCLH Biomedical Research Centre
University College London
Jacobs Foundation2017-1261-04, MQF17/24
Wellcome Trust211155, 098362, 098362/Z/12/Z, 095844/7/11/Z
Wellcome Sir Henry Dale Fellowship211155/Z/18/Z
Sir Henry Wellcome Trust10739/Z/15/Z/
Medical Research CouncilSUAG/014 RG91365
Engineering and Physical Sciences Research CouncilEP/N510129/1

    Keywords

    • Adolescence
    • Compulsivity
    • Development
    • Frontostriatal connectivity
    • Model-based control

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