'Compulsive' lever pressing in rats is enhanced following lesions to the orbital cortex, but not to the basolateral nucleus of the amygdala or to the dorsal medial prefrontal cortex

Daphna Joel*, Julia Doljansky, Daniela Schiller

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

In a new rat model of obsessive-compulsive disorder (OCD), 'compulsive' behaviour is induced by attenuating a signal indicating that a lever-press response was effective in producing food. We have recently found that compulsive lever pressing is increased following lesions to the rat orbital cortex, in accordance with several lines of evidence implicating the orbitofrontal cortex in the pathophysiology of OCD. In view of the functional similarities between the orbital cortex, the basolateral nucleus of the amygdala and the medial prefrontal cortex, the present study compared the effects of lesions to these three regions. The present study replicated the finding that lesions to the rat orbital cortex enhance compulsive lever pressing. In contrast, lesions to the dorsal medial prefrontal cortex and to the basolateral amygdala did not affect compulsive lever pressing. A comparison of these findings to current knowledge regarding similarities and differences in the functioning of the three regions sheds light on the mechanism by which signal attenuation induces compulsive lever pressing and on the role played by the orbital cortex in compulsive behaviour.

Original languageEnglish
Pages (from-to)2252-2262
Number of pages11
JournalEuropean Journal of Neuroscience
Volume21
Issue number8
DOIs
StatePublished - Apr 2005

Keywords

  • Animal model
  • Conditioned reinforcement
  • Obsessive-compulsive disorder (OCD)
  • Orbitofrontal cortex
  • Reinforcer devaluation
  • Signal attenuation

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