Compounds from the marine sponge Cribrochalina vasculum offer a way to target IGF-1R mediated signaling in tumor cells

Medicine and Dentistry

• Tumor Cell 100%
• In Silico 50%
• Tyrosine-Kinase Inhibitor 50%
• Cancer Treatment 50%
• Fibroblast 50%
• Neoplasm 50%
• Therapeutic Agent 50%
• Gene Expression Profiling 50%
• Epidermal Growth Factor Receptor 50%
• Phosphotransferase 50%
• Insulin Receptor 50%
• Signaling Molecule 50%
• Binding Site 50%
• Tyrosine Kinase Receptor 50%
• Somatomedin Receptor 50%
• Phosphoinositide Dependent Protein Kinase 1 50%
• Alcohol Derivative 50%
• Non Small Cell Lung Cancer 50%
• 3 Bromo 5 Tert Butyl 4 Hydroxybenzylidenemalononitrile 50%

Keyphrases

• Insulin-like Growth Factor 1 Receptor (IGF1R) 100%
• Tumor Cells 100%
• Marine Sponge 100%
• IGF1R Signaling 40%
• Novel Therapeutics 20%
• Mechanism of Action 20%
• Binding Site 20%
• Kinase Domain 20%
• Phosphorylation 20%
• Tyrosine Kinase Inhibitor 20%
• Fibroblasts 20%
• Gene Expression Analysis 20%
• Pro-survival 20%
• Antitumor Efficacy 20%
• Non-small Cell Lung Cancer (NSCLC) 20%
• Compound II 20%
• Signaling Molecules 20%
• Antitumor Effect 20%
• Tyrosine Kinase Receptor 20%
• Insulin Receptor 20%
• Insulin Receptor Substrate 1 (IRS1) 20%
• AG1024 20%
• Receptor Degradation 20%
• PDK1 20%
• Alcohol Molecules 20%
• Antitumor Treatment 20%
• Insulin-like Growth Factor Receptor 20%
• Acetylene Alcohols 20%
• In Silico Docking 20%
• Cellular Thermal Shift Assay (CETSA) 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Neoplasm 100%
• Phosphotransferase 25%
• Binding Site 25%
• Epidermal Growth Factor Receptor 25%
• Protein Tyrosine Kinase Inhibitor 25%
• Insulin Receptor 25%
• Tyrosine Kinase Receptor 25%
• Somatomedin Receptor 25%
• Alcohol Derivative 25%
• Non Small Cell Lung Cancer 25%
• 3 Bromo 5 Tert Butyl 4 Hydroxybenzylidenemalononitrile 25%
• Phosphoinositide Dependent Protein Kinase 1 25%